Mechanisms for T cell tolerance induced with granulocyte colony-stimulating factor
| Autor: | Li-Xia Sun, Jian-Zhu Yang, Jin-Qiao Zhang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
T-Lymphocytes T cell Immunology Graft vs Host Disease Biology Autoimmune Diseases Immune tolerance 03 medical and health sciences Interleukin 21 0302 clinical medicine Granulocyte Colony-Stimulating Factor Immune Tolerance medicine Animals Humans Cytotoxic T cell IL-2 receptor Antigen-presenting cell Molecular Biology FOXP3 030104 developmental biology medicine.anatomical_structure CTLA-4 030215 immunology |
| Zdroj: | Molecular Immunology. 70:56-62 |
| ISSN: | 0161-5890 |
| DOI: | 10.1016/j.molimm.2015.12.006 |
| Popis: | Granulocyte colony-stimulating factor (G-CSF) has been widely accepted as a mediator of T cell tolerance. The immune modulatory effect of G-CSF on T cells is believed to be mediated exclusively through other effector cells, such as monocytes, tolerogenic dendritic cells (DC), and myeloid-derived suppressor cells. Recent advances confirmed the direct effects of G-CSF in inducing immune tolerance of T cells through the G-CSF-G-CSF receptor pathway and related molecular mechanisms. This review aims to summarize the findings associated with the direct and indirect mechanisms for T cell tolerance induced with G-CSF. The role of G-CSF in preventing graft-versus-host disease (GVHD) and in treating autoimmune diseases (ADs) is also discussed. It is conceivable that G-CSF and immune cell compositions, such as tolerogenic DC and CD4(+)CD25(+)Foxp3(+) T cells, modulated by G-CSF could become an integral part of the immunomodulatory therapies against GVHD and ADs in the future. |
| Databáze: | OpenAIRE |
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