Defining the Histopathological Term Atypical Intraepidermal Melanocytic Proliferation: A Retrospective Cross-Sectional Study
| Autor: | Julio E. Sánchez, Carlos J. Sarriera-Lázaro, Alfredo Bou-Prieto, Jorge L. Sánchez, Sheila M. Valentín-Nogueras |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Skin Neoplasms Adolescent Cross-sectional study Biopsy Dermatology Malignancy Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Predictive Value of Tests Internal medicine Terminology as Topic medicine Biomarkers Tumor Humans Risk factor Child Melanoma Aged Cell Proliferation Retrospective Studies Aged 80 and over Punch Biopsy business.industry Infant Newborn Infant General Medicine Odds ratio Biological potential Middle Aged medicine.disease Immunohistochemistry Cross-Sectional Studies Child Preschool Melanocytes Female business |
| Zdroj: | The American Journal of dermatopathology. 43(4) |
| ISSN: | 1533-0311 |
| Popis: | Background Atypical intraepidermal melanocytic proliferation (AIMP) is a general term assigned to melanocytic proliferations of uncertain biological potential when a definitive histopathological diagnosis cannot be achieved. There are few data available describing the possibility of malignancy of AIMP, or ways to further define diagnosis. Objective To determine the rate of diagnostic change of AIMP to melanoma or melanoma in situ (MIS) after conventional excision. In addition, to determine the role of immunohistochemistry (IHC) in defining AIMP biopsies. Methods Retrospective cross-sectional, single-center review of biopsies with a diagnosis of AIMP with a follow-up conventional excision from 2012-2016 was performed. In a separate analysis, a search was performed for AIMP biopsied lesions in which IHC was subsequently performed. Results The rate of diagnostic change of AIMP to MIS was 4.8% (8/167) after excision. Punch biopsy was a risk factor for diagnostic change to MIS (odds ratio 12.94, confidence interval 2.56-65.38, P = 0.008). The rate of diagnostic change of AIMP biopsies after examining with IHC was 21.3% (34/160) to MIS and 4.4% (7/160) to melanoma. Conclusion The possibility of malignancy of AIMP lesions must be taken into consideration when counseling patients and when planning treatment options. IHC is a useful tool and should be used in the evaluation of AIMP specimens. |
| Databáze: | OpenAIRE |
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