Porcine Cysticercosis: Possible Cross-Reactivity of Taenia hydatigena to GP50 Antigen in the Enzyme-Linked Immunoelectrotransfer Blot Assay

Autor: Victor C. W. Tsang, Robert H. Flecker, Pierre Dorny, Ricardo Gamboa, Armando E. Gonzalez, Hector H. Garcia, Claudio Muro, Robert H. Gilman, Luis A. Gomez-Puerta, Seth E. O’Neal, Percy Vilchez Barreto
Rok vydání: 2017
Předmět:
0301 basic medicine
Swine/parasitology
030231 tropical medicine
Cross Reactions
medicine.disease_cause
Sensitivity and Specificity
Cross-reactivity
Host-Parasite Interactions
Microbiology
Serology
03 medical and health sciences
0302 clinical medicine
Antigen
Virology
Peru
parasitic diseases
Taenia solium
medicine
Animals
Taeniasis
Nerve Tissue Proteins/blood
Taenia hydatigena
Antibodies
Helminth/blood
biology
Swine Diseases/blood/diagnosis/parasitology
Cysticercosis
Dogs/parasitology
030108 mycology & parasitology
Antigens
Helminth/blood
biology.organism_classification
medicine.disease
medicine.drug_formulation_ingredient
Infectious Diseases
Cysticercosis/blood/diagnosis/veterinary
Taenia
Parasitology
Taenia/classification/isolation & purification
Biomarkers/blood
purl.org/pe-repo/ocde/ford#3.03.06 [https]
Zdroj: The American Journal of Tropical Medicine and Hygiene. 97:1830-1832
ISSN: 1476-1645
0002-9637
DOI: 10.4269/ajtmh.17-0378
Popis: The lentil lectin glycoprotein enzyme-linked immunoelectrotransfer blot (LLGP EITB, reported sensitivity 99% and specificity 100%) is used as a serologic marker of exposure to Taenia solium in pigs. However, only a limited number of parasites have been evaluated for cross reactivity. Pigs may host other related cestode infections, including Taenia hydatigena, which have not been formally evaluated for cross-reactions. We investigated a corral in Tumbes, Peru, a region where a cysticercosis elimination demonstration project was completed in 2012. In this corral, 14/19 (73.7%) 6-8-week-old piglets were reactive to GP50 on LLGP EITB, and all had circulating Taenia sp. antigens. From eight necropsied piglets; four were infected with T. hydatigena metacestodes whereas none had evidence of T. solium infection. Two resident dogs were subsequently confirmed to have T. hydatigena taeniasis. These results suggest GP50 cross-reactivity in T. hydatigena-infected pigs, although controlled experimental infection is needed to confirm this hypothesis.
Databáze: OpenAIRE
Externí odkaz: