Incomplete Reversal of Enoxaparin-Induced Bleeding by Protamine Sulfate
| Autor: | Ingebrigt Talstad, C J Bang, Arnold Berstad |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Tail Bleeding Time Protamine sulfate medicine.drug_class medicine.medical_treatment Rat model Blood Pressure Hemorrhage Pharmacology Primary hemostasis Physiology (medical) Coagulopathy Gastric mucosa Animals Medicine Protamines Skin Chemotherapy business.industry Anticoagulant Rats Inbred Strains Hematology Heparin Low-Molecular-Weight medicine.disease Rats medicine.anatomical_structure Gastric Mucosa Anesthesia business medicine.drug |
| Zdroj: | Pathophysiology of Haemostasis and Thrombosis. 21:155-160 |
| ISSN: | 1424-8840 1424-8832 |
| DOI: | 10.1159/000216220 |
| Popis: | The neutralizing effect of protamine sulfate on enoxaparin-induced bleeding was compared in two rat models: one employing the gastric mucosa, and the other the tail skin, using a 2:1 ratio of protamine sulfate to enoxaparin on a weight basis. Whereas protamine sulfate reduced the median bleeding time (from 20 to 9.5 min) and blood loss (80%) in the gastric mucosa, an apparent ‘all-or-none’ response was seen in the tail skin, in agreement with a different hemostatic mechanism in the two bleeding models. In both models, protamine sulfate incompletely reversed the bleeding induced by enoxaparin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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