Amphiphilic Fullerene‐BODIPY Photosensitizers for Targeted Photodynamic Therapy
| Autor: | Ezel Öztürk Gündüz, M. Emre Gedik, Gürcan Günaydın, Elif Okutan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Boron Compounds
Fullerene medicine.medical_treatment Photodynamic therapy Conjugated system Biochemistry chemistry.chemical_compound Neoplasms Drug Discovery Amphiphile medicine Humans MTT assay General Pharmacology Toxicology and Pharmaceutics Pharmacology chemistry.chemical_classification Reactive oxygen species Photosensitizing Agents Singlet Oxygen Singlet oxygen Organic Chemistry Combinatorial chemistry Glucose Photochemotherapy chemistry Molecular Medicine Fullerenes BODIPY |
| Zdroj: | ChemMedChem. 17 |
| ISSN: | 1860-7187 1860-7179 |
| DOI: | 10.1002/cmdc.202100693 |
| Popis: | Nanotheranostic tailor-made carriers are potent platforms for the treatment of cancer that propound a number of advantages over conventional agents for photodynamic therapy (PDT). Herein, four new heavy atom free amphiphilic glucose-BODIPY-fullerene dyads ( 14 - 17 ) endowed with carbohydrate moieties in the styryl units, that can also form nanomicelles ( 14 - 17NM) with Tween 80 for PDT are reported. Glucose-BODIPY-fullerene systems ( 14 - 17 ) and related nanomicelles ( 14 - 17NM ) have been prepared to emcee efficient singlet oxygen generation upon light irradiation. In vitro anti-tumor effects of the compounds 14 - 17 and 14 - 17NM in the presence of light and in darkness have been investigated with K562 human chronic myelogenous leukemia suspension cells. Anti-tumor toxicity upon light irradiation was due to the formation of singlet oxygen and reactive oxygen species (ROS). This study may provide an accomplished example of efficient PDT applications based on nanovehicles fabricated with universal spin converter, fullerene, light harvesting unit, BODIPY dyes conjugated with targeting units to fight against cancer. |
| Databáze: | OpenAIRE |
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