African swine fever virus (ASFV) protection mediated by NH/P68 and NH/P68 recombinant live-attenuated viruses
| Autor: | Daniel Pérez-Núñez, Marisa Nogal, Angel L. Carrascosa, Yolanda Revilla, Carmina Gallardo, Elena G. Sánchez, Alejandro Soler, Patricia de León, María Luisa Arias, Raquel Nieto |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Swine 030106 microbiology Armenia07/Arm07 Virulence Vaccines Attenuated African swine fever virus 03 medical and health sciences Viral Proteins Immune system Antigen Chlorocebus aethiops Deletion mutants Animals African Swine Fever Recombinants Pathogen Gene Attenuated vaccine General Veterinary General Immunology and Microbiology biology Public Health Environmental and Occupational Health Viral Vaccines biology.organism_classification Virology African Swine Fever Virus LAVs 030104 developmental biology Infectious Diseases Viral replication COS Cells Host-Pathogen Interactions Mutation Molecular Medicine NH/P68 ASFV |
| Zdroj: | Repositorio de Resultados de Investigación del INIA INIA: Repositorio de Resultados de Investigación del INIA Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA |
| Popis: | The risk of spread of African swine fever virus (ASFV) from Russia and Caucasian areas to several EU countries has recently emerged, making it imperative to improve our knowledge and defensive tools against this important pathogen. The ASFV genome encodes many genes which are not essential for virus replication but are known to control host immune evasion, such as NFκB and the NFAT regulator A238L, the apoptosis inhibitor A224L, the MHC-I antigen presenting modulator EP153R, and the A276R gene, involved in modulating type I IFN. These genes are hypothesized to be involved in virulence of the genotype I parental ASFV NH/P68. We here describe the generation of putative live attenuated vaccines (LAV) prototypes by constructing recombinant NH/P68 viruses lacking these specific genes and containing specific markers. |
| Databáze: | OpenAIRE |
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