Cytokine-mediated Inhibition of Erythropoietin Synthesis by Dexamethasone
| Autor: | P. I. Folb, H. M. J. Leng, G. W. Randall, S. H. Kidson, M. M. Keraan |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Necrosis medicine.medical_treatment Anti-Inflammatory Agents Pharmaceutical Science Biology Dexamethasone Monocytes Cell Line Proinflammatory cytokine hemic and lymphatic diseases Internal medicine medicine Humans Erythropoietin Pharmacology Interleukin-6 Tumor Necrosis Factor-alpha Monocyte Haematopoiesis medicine.anatomical_structure Cytokine Endocrinology Cell culture Culture Media Conditioned Cytokines Indicators and Reagents medicine.symptom Interleukin-1 medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 48:971-974 |
| ISSN: | 2042-7158 0022-3573 |
| Popis: | The effect of inflammatory cytokines on the in-vitro synthesis of erythropoietin by HepG2 cells was evaluated. Monocyte-conditioned medium, and the cytokines interleukin-1β, interleukin-6 and tumour necrosis factor-α all reduced synthesis of erythropoietin. The steroidal anti-inflammatory drug, dexamethasone, did not affect cytokine-mediated erythropoietin inhibition. Dexamethasone did cause a reduction in the secretion of erythropoietin inhibitory cytokines from monocytes. These results point to a possible therapeutic approach in the treatment of anaemia caused by suppression of erythropoietin synthesis by monocytic cytokines. |
| Databáze: | OpenAIRE |
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