Interferon-gamma release assay versus tuberculin skin test for latent tuberculosis infection among HIV patients in Brazil
| Autor: | Sonia Mara Raboni, Andrea Maciel de Oliveira Rossoni, Libera Maria Dalla-Costa, Gislene Maria Botão Kussen |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty 030106 microbiology lcsh:QR1-502 Interferon gamma release assay Tuberculin HIV Infections Sensitivity and Specificity lcsh:Microbiology lcsh:Infectious and parasitic diseases Cohort Studies Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Latent Tuberculosis Predictive Value of Tests Internal medicine medicine Humans lcsh:RC109-216 Prospective Studies 030212 general & internal medicine Seroconversion Prospective cohort study Immunological tests Medicine(all) Latent tuberculosis biology Tuberculin Test business.industry Middle Aged bacterial infections and mycoses medicine.disease biology.organism_classification Infectious Diseases Predictive value of tests Immunology Immunocompromised patients Female business Interferon-gamma Release Tests Cohort study |
| Zdroj: | Brazilian Journal of Infectious Diseases v.20 n.1 2016 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Vol 20, Iss 1, Pp 69-75 (2016) Brazilian Journal of Infectious Diseases, Volume: 20, Issue: 1, Pages: 69-75, Published: FEB 2016 |
| ISSN: | 1413-8670 |
| DOI: | 10.1016/j.bjid.2015.10.007 |
| Popis: | Setting: Patients HIV+ attending in a reference clinic, Southern Brazil. Objective: To compare the interferon-gamma-release assay (IGRA – QuantiFERON® TB Gold In-Tube) with the tuberculin skin test (TST – PPD-Rt 23) for latent tuberculosis infection (LTBI) in patients with HIV. Design: Cohort study. Patients were simultaneously submitted to the TST and blood collection for the IGRA. Results: A total of 140 subjects were included. Nine (6.4%) were IGRA+/TST+, 12 (8.6%) were IGRA+/TST−, 4 (3%) were IGRA−/TST+, and 115 (82%) IGRA−/TST−. There was poor agreement between tests (kappa = 0.2), and no correlation between these results and CD4+ T lymphocyte counts. During follow-up, one patient with negative results on both tests died from sepsis, and another with discordant results (IGRA+/TST−) exhibited TST seroconversion. Compared to the TST, IGRA showed a sensitivity and specificity of 69% and 90%, respectively. The IGRA detected 8% more positive results than the TST. All patients were followed up for 2 years. Conclusion: The higher accuracy of the IGRA would result in LTBI treatments being administered to patients who would have otherwise been overlooked, decreasing the number of active tuberculosis cases. The long-term survival of HIV carriers requires further evaluation. Keywords: Mycobacterium tuberculosis, Immunological tests, Immunocompromised patients |
| Databáze: | OpenAIRE |
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