Tissue plasminogen activator levels in different types of polycythemia
| Autor: | D. Creter, A. Kadouri, Amos Cohen, A. Gelvan, Meir Djaldetti |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Secondary Polycythemia Polycythemia Hematocrit Tissue plasminogen activator Hemoglobins Polycythemia vera hemic and lymphatic diseases Internal medicine Thromboembolism Blood plasma medicine Humans Polycythemia Vera Aged Aged 80 and over medicine.diagnostic_test business.industry Hematology General Medicine Middle Aged medicine.disease Thrombosis Endocrinology Tissue Plasminogen Activator Hemoglobin business Plasminogen activator medicine.drug |
| Zdroj: | European journal of haematology. 45(1) |
| ISSN: | 0902-4441 |
| Popis: | The plasma level of tissue plasminogen activator antigen (t-PA-Ag) was examined in 86 patients with polycythemia (29 polycythemia vera, 11 secondary polycythemia and 46 with spurious polycythemia) and 24 healthy volunteers. Tissue plasminogen activator antigen was significantly decreased in patients with polycythemia vera in comparison with healthy controls. On the other hand, in patients with spurious polycythemia and secondary polycythemia t-PA-Ag concentration was significantly increased. There was no significant difference in t-PA-Ag levels in polycythemic patients with or without thromboembolic disease. A significant correlation was detected between t-PA-Ag level and hemoglobin or hematocrit concentration in patients with polycythemia vera (p = 0.02, r = 0.43). However, in patients with secondary polycythemia and spurious polycythemia, no significant correlation between t-PA-Ag and hemoglobin level was found. Plasminogen activator inhibitor (PAI) levels in patients with polycythemia vera and healthy volunteers did not differ significantly. |
| Databáze: | OpenAIRE |
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