Amelioration of Ethanol-Induced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (Spirulina) Maxima
| Autor: | Nora Lilia Rivero-Ramírez, Julia Pérez-Ramos, Emmanuel Ríos-Castro, Rosa Virginia García-Rodríguez, Ricardo Pérez-Pastén-Borja, Lucía Quevedo-Corona, Oscar Guzmán-Gómez, Salud Pérez-Gutiérrez, Germán Chamorro-Cevallos |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment lcsh:TX341-641 Pharmacology Ulcer index Lipid peroxidation Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Arthrospira (Spirulina) maxima Gastric mucosa medicine antiulcerogenic chemistry.chemical_classification Nutrition and Dietetics biology Glutathione peroxidase Stomach biology.organism_classification digestive system diseases 030104 developmental biology medicine.anatomical_structure chemistry phycobiliproteins biology.protein ethanol Arthrospira lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients, Vol 10, Iss 6, p 763 (2018) Nutrients Volume 10 Issue 6 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu10060763 |
| Popis: | Phycobiliproteins of Arthrospira (Spirulina) maxima have attracted attention because of their potential therapeutic antioxidant properties. The aim of this study was to assess the possible antiulcerogenic activity of these phycobiliproteins (ExPhy) against ethanol-induced gastric ulcers in rats. To explore the possible mechanisms of action, we examined antioxidant defense enzymes (e.g., catalase, superoxide dismutase, and glutathione peroxidase), as well as the level of lipid peroxidation (MDA) and the histopathological changes in the gastric mucosa. Intragastric administration of ExPhy (100, 200, and 400 mg/kg body weight) significantly lowered the ulcer index value compared to the ulcer control group (p < 0.05). The greatest protection was provided by the concentration of 400 mg/kg. The histological study supported the observed gastroprotective activity of ExPhy, showing a reduced inflammatory response. Moreover, the alcohol-induced decrease in stomach antioxidant enzyme activity found in the ulcer control group was prevented by ExPhy pretreatment. Furthermore, ExPhy reversed the ethanol-induced increase in lipid peroxidation. In summary, the antiulcerogenic potential of ExPhy may be due, at least in part, to its anti-oxidant and anti-inflammatory effects. |
| Databáze: | OpenAIRE |
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