Sex differences in the strategies of spatial learning in prenatally-exposed rats treated with various drugs in adulthood
| Autor: | E. Macúchová, Kateryna Nohejlová, Romana Šlamberová, Mária Ševčíková, I. Hrebíčková |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Drug N-Methyl-3 4-methylenedioxyamphetamine media_common.quotation_subject medicine.medical_treatment Spatial Learning Physiology Morris water navigation task Pharmacology Methamphetamine Random Allocation 03 medical and health sciences Behavioral Neuroscience Cognition 0302 clinical medicine Cocaine Pregnancy medicine Animals Dronabinol Rats Wistar Saline media_common Psychological Tests Psychotropic Drugs Sex Characteristics Thigmotaxis Morphine Recall MDMA 030104 developmental biology Prenatal Exposure Delayed Effects Female Psychology 030217 neurology & neurosurgery Spatial Navigation medicine.drug |
| Zdroj: | Behavioural Brain Research. 327:83-93 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2017.03.041 |
| Popis: | In the present study we investigated the sex differences in the effect of adult long-term drug treatment on cognitive functions of Wistar rats, which were prenatally exposed to MA (5 mg/kg) or saline. Cognitive functions were tested as an ability of spatial learning in the Morris Water Maze (MWM), which consisted of three types of tests: “Place Navigation Test”; “Probe Test”, and “Memory Recall Test”. Adult animals were injected daily, after completion of the last trial, either with saline or cocaine (COC; 5 mg/kg), MDMA (3,4-methylenedioxy-methamphetamine; 5 mg/kg), morphine (MOR; 5 mg/kg), or delta-9-tetrahydrocannabinol (THC; 2 mg/kg). Results revealed worsened MWM performance in female rats after drug treatment in adulthood. Not only were traditionally investigated parameters affected by drug treatment (latency of platform acquisition, search strategy, distance traveled), but also strategies used by animals (thigmotaxis, scanning). Analyses of search strategies observed in the Place Navigation Test, as well as in the Memory Recall Test, demonstrated variations in the percentage of time spent in thigmotaxis and scanning in females after treatment with COC, MDMA, MOR, and THC. Although we did not see a sensitizing effect of prenatal MA, in some cases the effect of drug treatment in adulthood differed depending on the prenatal drug exposure. The data presented in this study demonstrates that exposure to drugs with various mechanisms of action alters spatial abilities of female rats in the MWM. Alterations in the effect of adult drug treatment with reference to prenatal drug exposure were also found in the present study. |
| Databáze: | OpenAIRE |
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