Association between exhaled carbon monoxide and asthma outcomes in Peruvian children
| Autor: | Karina Romero, Gasp Study Investigators, John J. Lima, Suzanne L. Pollard, Nadia N. Hansel, Amanda Pereira, William Checkley, Robert Locke |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Adolescent Logistic regression Severity of Illness Index Odds 03 medical and health sciences 0302 clinical medicine Asthma control Environmental health Peru parasitic diseases Severity of illness Humans Medicine 030212 general & internal medicine Child Asthma Carbon Monoxide business.industry medicine.disease respiratory tract diseases Uncontrolled asthma Logistic Models Breath Tests 030228 respiratory system Quartile Health Resources Female business Biomarkers Asthma Control Test |
| Zdroj: | Respiratory Medicine. 145:212-216 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2018.11.005 |
| Popis: | Background Asthma prevalence continues to increase in low and middle-income countries, presenting challenges in assessing asthma control in resource-poor settings. Previous studies suggest that exhaled carbon monoxide (eCO) is higher with asthma severity and lower with treatment. We hypothesized that eCO levels may be elevated in children with asthma, particularly in children with partially controlled or uncontrolled asthma in a low-resource setting in Lima, Peru. Methods We compared average eCO levels between 248 children with asthma and 221 healthy controls as well as the odds of asthma by eCO quartiles (0–1, 2, 3, and ≥4 ppm) using multivariable linear and logistic regression. eCO quartiles were also used to compare the odds of partially controlled or uncontrolled asthma (score ≤19 on the Asthma Control Test) in a multivariable logistic regression model. Findings Average adjusted eCO level was 0.56 ppm (95% CI 0.07–1.05) higher in children with asthma. The adjusted odds of asthma were 1.22 (95% CI 0.75–1.97), 1.46 (0.81–2.63), and 1.76 (0.96–3.23) in the second, third, and fourth eCO quartiles compared to the first eCO quartile, respectively. Among children with asthma, the adjusted odds of partially controlled or uncontrolled asthma in those in the second, third, and fourth eCO quartiles, compared to the first, were 1.61 (95% CI 0.74–3.48), 3.66 (95% CI 1.51–8.87), and 2.50 (95% CI 1.06–5.90), respectively. Interpretation eCO may serve as an inexpensive biomarker for asthma control, particularly in low-resource settings. |
| Databáze: | OpenAIRE |
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