The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea
| Autor: | Min-Gyu Yoo, Keon Jae Park, Han Byul Jang, Yoo Jeong Lee, Hyeon-Kyeong Kim, Sang Ick Park, Sung-Gon Kim, Hye-Ja Lee |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Alcoholic liver disease Health (social science) Alcohol Drinking Genotype Physiology Alcohol Acetaldehyde Toxicology Polymorphism Single Nucleotide Biochemistry 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine GTP-Binding Proteins Proto-Oncogene Proteins Republic of Korea medicine Humans Ethanol metabolism Alleles Alcohol dehydrogenase ALDH2 biology business.industry Alcohol dependence Alcohol Dehydrogenase ADH1A General Medicine medicine.disease 030227 psychiatry Phosphoglucomutase Neurology chemistry biology.protein Blood Alcohol Content Female business 030217 neurology & neurosurgery |
| Zdroj: | Alcohol. 79:137-145 |
| ISSN: | 0741-8329 |
| Popis: | Background Excessive alcohol consumption is a major public health problem in East Asian countries. Alcohol use leads to a cascade of problems including increased chances of risky behavior and a wide range of negative health consequences, from alcoholic liver disease to upper gastric and liver cancer. These alcohol effects are known to be influenced by ethnic variability and genetics. Methods In this study, subjects were administered a single dose of alcohol (0.6 g/kg for men or 0.4 g/kg for women), and blood alcohol and acetaldehyde concentrations were measured eight times over 5 hours. To investigate genetically susceptible factors to alcohol metabolism, we selected single-nucleotide polymorphisms (SNP) of genes identified by prior genetic association studies for alcohol metabolism, alcohol consumption, alcohol dependence, and related traits, and performed genotyping on all subjects (n = 104). Results We identified variations in the ADH1A, SRPRB, and PGM1 genes, which are directly associated with blood alcohol or acetaldehyde concentrations. Namely, the T allele of SRPRB rs17376019 and the C allele of PGM1 rs4643 were associated with lower blood alcohol levels, while the ADH1 rs1229976 C allele group exhibited markedly higher blood acetaldehyde levels than those of the ADH1 rs1229976 T allele group. Conclusion This study demonstrates that genetic variations in ADH1A, SRPRB, and PGM1 are associated with variations in blood alcohol and acetaldehyde concentration after alcohol intake. |
| Databáze: | OpenAIRE |
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