| Autor: |
Dong Hyun Kim, Seung Gi Min, Hun-Min Kim, Hae Rim Kang, Jin-Hyun Choi, Hyun Joo Lee, Kyung-Rock Kim, Seok Won Chung, Jong Pil Yoon |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Orthopedics. 45(3) |
| ISSN: |
1938-2367 |
| Popis: |
This study evaluated the biomechanical and histologic characteristics of the rotator cuff tendon and muscle tissue with rat models with diabetes mellitus (DM) (group 1) and 30 male rats without DM (group 2). We conducted a time zero study without any additional procedures or external variables at 9 weeks after induction of the diabetic rat model. Thereafter, quantitative evaluation of advanced glycation end products (AGEs) was accomplished via enzyme-linked immunosorbent assay and immunohistochemistry (IHC). Fatty infiltration was investigated with Oil Red O staining, and the peroxisome proliferator activated receptor-gamma (PPAR-gamma) value was studied with IHC. Grossly, the supraspinatus tendons of the group 1 rats were more friable and discolored (yellowish) than those of group 2. In the biomechanical analysis, group 1 rats showed significantly inferior ultimate failure load ( P =.001) and ultimate stress ( P =.02). Group 1 was significantly inferior to group 2 in terms of total histologic scoring ( P P P P =.14). The intact rotator cuffs of rats with DM were associated with inferior biomechanics in association with AGE accumulation and increased fatty infiltration, as confirmed by histologic examination The hyperglycemic state caused by DM is associated with rotator cuff tendon degeneration. [ Orthopedics . 2022;45(3):e154–e161.] |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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