Role of the Left Atrial Appendage in Systemic Homeostasis, Arrhythmogenesis, and Beyond
| Autor: | Bharath Yarlagadda, Krishna Akella, Dhanunjaya Lakkireddy, Rakesh Gopinathannair, Andrea Natale, Domenico G. Della Rocca, Ghulam Murtaza |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Atrial natriuretic peptide Physiology (medical) Internal medicine Thromboembolism Atrial Fibrillation medicine Homeostasis Humans Atrial Appendage cardiovascular diseases 030212 general & internal medicine Thrombus Cardiac Surgical Procedures Stroke Appendage business.industry Cardiac arrhythmia Atrial fibrillation medicine.disease Compliance (physiology) cardiovascular system Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiac electrophysiology clinics. 12(1) |
| ISSN: | 1877-9190 |
| Popis: | The left atrial appendage (LAA) affects body homeostasis via atrial natriuretic peptide and the renin-angiotensin-aldosterone system and plays an important role in atrial compliance. Approximately 90% of clots in nonvalvular atrial fibrillation (AF) are formed in the LAA. AF is the most common sustained cardiac arrhythmia and is frequently associated with stroke. Because anticoagulation for stroke prophylaxis carries a higher bleeding risk, LAA closure via epicardial and endocardial approaches has gained popularity and is being increasingly pursued for arrhythmogenic, homeostatic, and stroke-reduction benefits. This review discusses the homeostatic role of the LAA and its involvement in arrhythmogenesis and thrombus formation. |
| Databáze: | OpenAIRE |
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