Melatonin prevents radiation-induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis
Autor: | Taner Arabaci, Oğuz Köse, Adem Kara, Mevlut Albayrak, Burak Erdemci, Alper Kızıldağ, Semin Gedikli, M. Zihni, Eda Kermen, Seckin Ozkanlar, D. Özkal Eminoğlu |
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Rok vydání: | 2016 |
Předmět: |
Male
Periodontium antioxidant interleukin 1beta medicine.medical_treatment Interleukin-1beta melatonin medicine.disease_cause Antioxidants Rats Sprague-Dawley chemistry.chemical_compound 0302 clinical medicine oxidative stress animal rat Melatonin Sprague Dawley rat Malondialdehyde 030220 oncology & carcinogenesis Periodontics medicine.drug medicine.medical_specialty radiation response tumor necrosis factor host modulation therapy 03 medical and health sciences N-terminal telopeptide blood Internal medicine medicine Animals Periodontitis radiotherapy Dental alveolus experimental periodontitis Radiotherapy Tumor Necrosis Factor-alpha business.industry disease model 030206 dentistry medicine.disease Antioxidants/*pharmacology Disease Models Animal Interleukin-1beta/blood Melatonin/*pharmacology Oxidative Stress/drug effects/*radiation effects Periodontitis/*metabolism/pathology Periodontium/*metabolism/pathology Radiotherapy/*adverse effects Rats Tumor Necrosis Factor-alpha/blood Radiation therapy Oxidative Stress Endocrinology chemistry drug effects Immunology pathology business metabolism Oxidative stress |
Zdroj: | Journal of Periodontal Research. 52:438-446 |
ISSN: | 0022-3484 |
Popis: | Background and Objective: The aim of this study was to analyze the biochemical and histochemical effects of radiation therapy and protective melatonin administration on periodontal tissues in rats with experimental periodontitis. Material and Methods: Sixty male Sprague Dawley rats were divided into six groups, as follows: control; experimental periodontitis (Ped); radiotherapy administration (Rt); experimental periodontitis and exposure to irradiation (Ped-Rt); radiotherapy and protective melatonin administration (Rt-Mel); and periodontitis, radiation therapy and protective melatonin administration (Ped-Rt-Mel). The rats were killed at the end of the experimental procedure, and the oxidative stress level and periodontal destruction were compared among the groups. Results: The oxidative stress index and the levels of 8-hydroxy-2'-deoxyguanosine, malondialdehyde and C-terminal telopeptide of type I collagen were found to be significantly higher in the Ped-Rt group compared with the Ped group (p < 0.05), and the levels were lower in the Ped-Rt-Mel group than in the Ped-Rt group (p < 0.05). Alveolar bone destruction and attachment level were also significantly lower in the Ped-Rt-Mel group than in the Ped-Rt group (p < 0.05). Conclusion: It was found that radiotherapy increased oxidative stress, the periodontal attachment level and alveolar bone loss, and protective melatonin administration significantly reduced the oxidative parameters and prevented periodontal damage in irradiated rats with experimental periodontitis. Further research is needed regarding the use of systemic melatonin administration before radiation therapy. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
Databáze: | OpenAIRE |
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