Melatonin prevents radiation-induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis

Autor: Taner Arabaci, Oğuz Köse, Adem Kara, Mevlut Albayrak, Burak Erdemci, Alper Kızıldağ, Semin Gedikli, M. Zihni, Eda Kermen, Seckin Ozkanlar, D. Özkal Eminoğlu
Rok vydání: 2016
Předmět:
Male
Periodontium
antioxidant
interleukin 1beta
medicine.medical_treatment
Interleukin-1beta
melatonin
medicine.disease_cause
Antioxidants
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
oxidative stress
animal
rat
Melatonin
Sprague Dawley rat
Malondialdehyde
030220 oncology & carcinogenesis
Periodontics
medicine.drug
medicine.medical_specialty
radiation response
tumor necrosis factor
host modulation therapy
03 medical and health sciences
N-terminal telopeptide
blood
Internal medicine
medicine
Animals
Periodontitis
radiotherapy
Dental alveolus
experimental periodontitis
Radiotherapy
Tumor Necrosis Factor-alpha
business.industry
disease model
030206 dentistry
medicine.disease
Antioxidants/*pharmacology
Disease Models
Animal
Interleukin-1beta/blood
Melatonin/*pharmacology
Oxidative Stress/drug effects/*radiation effects
Periodontitis/*metabolism/pathology
Periodontium/*metabolism/pathology
Radiotherapy/*adverse effects
Rats
Tumor Necrosis Factor-alpha/blood
Radiation therapy
Oxidative Stress
Endocrinology
chemistry
drug effects
Immunology
pathology
business
metabolism
Oxidative stress
Zdroj: Journal of Periodontal Research. 52:438-446
ISSN: 0022-3484
Popis: Background and Objective: The aim of this study was to analyze the biochemical and histochemical effects of radiation therapy and protective melatonin administration on periodontal tissues in rats with experimental periodontitis. Material and Methods: Sixty male Sprague Dawley rats were divided into six groups, as follows: control; experimental periodontitis (Ped); radiotherapy administration (Rt); experimental periodontitis and exposure to irradiation (Ped-Rt); radiotherapy and protective melatonin administration (Rt-Mel); and periodontitis, radiation therapy and protective melatonin administration (Ped-Rt-Mel). The rats were killed at the end of the experimental procedure, and the oxidative stress level and periodontal destruction were compared among the groups. Results: The oxidative stress index and the levels of 8-hydroxy-2'-deoxyguanosine, malondialdehyde and C-terminal telopeptide of type I collagen were found to be significantly higher in the Ped-Rt group compared with the Ped group (p < 0.05), and the levels were lower in the Ped-Rt-Mel group than in the Ped-Rt group (p < 0.05). Alveolar bone destruction and attachment level were also significantly lower in the Ped-Rt-Mel group than in the Ped-Rt group (p < 0.05). Conclusion: It was found that radiotherapy increased oxidative stress, the periodontal attachment level and alveolar bone loss, and protective melatonin administration significantly reduced the oxidative parameters and prevented periodontal damage in irradiated rats with experimental periodontitis. Further research is needed regarding the use of systemic melatonin administration before radiation therapy. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Databáze: OpenAIRE
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