Evaluation of performance of co crystals of mefloquine hydrochloride in tablet dosage form
| Autor: | A. V. Yadav, M. S. Murthy, A. S. Shete |
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| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Models Molecular Materials science Chemistry Pharmaceutical Organic Chemistry Pharmaceutical Science Biological Availability Cocrystal Mefloquine Hydrochloride Dosage form Drug content Mefloquine Crystallography Antimalarials Drug Stability Solubility Drug Discovery Crystallization Dissolution Biological availability Nuclear chemistry Tablets |
| Zdroj: | Drug development and industrial pharmacy. 39(5) |
| ISSN: | 1520-5762 |
| Popis: | Objective: The objective of present investigation was to evaluate performance of cocrystals of Mefloquine Hydrochloride (MFL) in tablet dosage form. Our previous investigation showed significant effect of cocrystal formers on improving the solubility and dissolution rate of Mefloquine hydrochloride by cocrystallization method when prepared by solution cocrystallization method.Materials and methods: Prepared cocrystals of MFL with different ratio of cocrystal formers were incorporated in tablet dosage form and evaluated for micrometric properties, drug content, hardness, disintegration test, vitro dissolution studies and stability studies. Performance was compared with laboratory prepared tablet of MFL 250 mg.Results: The considerable improvement in the dissolution rate was observed in case of cocrystals based tablets than pure MFL tablets.Discussion and conclusion: So we can incorporate cocrystals in tablet dosage form to enhance in vitro and in vivo performance. To the best of our knowledge, this is the ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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