Cytokine Responses to Specific Immunotherapy in House Dust Mite-Induced Allergic Rhinitis Patients
| Autor: | Hong Li, Enxiu Xu, Mingqiang He |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Time Factors medicine.medical_treatment Immunology Severity of Illness Index Young Adult Interferon medicine Animals Humans Immunology and Allergy Cells Cultured House dust mite Sublingual Immunotherapy biology business.industry Interleukin-17 Pyroglyphidae Remission Induction Therapeutic effect Interleukin Immunotherapy Middle Aged biology.organism_classification Rhinitis Allergic Slit Treatment Outcome Cytokine Case-Control Studies Leukocytes Mononuclear Cytokines Female Interleukin 17 Inflammation Mediators business Biomarkers medicine.drug |
| Zdroj: | Inflammation. 38:2216-2223 |
| ISSN: | 1573-2576 0360-3997 |
| DOI: | 10.1007/s10753-015-0204-3 |
| Popis: | Allergen-specific immunotherapy is the only immunomodulatory treatment that may alter the natural course of allergic disease. However, cytokine responses accompanying sublingual immunotherapy (SLIT) responder phenotypes have not been fully understood. Herein, we examined the level of crucial plasma cytokines during SLIT and evaluated whether their changes correlated to symptom scores. We observed that the levels of interleukin (IL)-17 and complement components C3a and C5a as well as IL-4 at year 3 of SLIT were significantly decreased than those at baseline. In contrast, there was no significant difference in the levels of IL-5, IL-13, and interferon (IFN)-γ. Notably, a significant positive correlation was found between the levels of IL-17 and the symptom scores at year 3. These results suggest that IL-17 could be considered a potential biomarker for the therapeutic effect of SLIT in allergic rhinitis caused by house dust mite. |
| Databáze: | OpenAIRE |
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