The meta and bioinformatics analysis of GRP78 expression in gastric cancer
| Autor: | Shuang Zhao, Bao-Cheng Gong, Hua-Chuan Zheng |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
GRP78
0301 basic medicine Oncology bioinformatics analysis medicine.medical_specialty Pathology Bioinformatics analysis Chromosomal translocation 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Grading (tumors) business.industry gastric cancer Endoplasmic reticulum Autophagy 030104 developmental biology Secretory protein Mrna level 030220 oncology & carcinogenesis Meta-analysis business Meta-Analysis meta analysis |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.20318 |
| Popis: | // Hua-Chuan Zheng 1 , Bao-Cheng Gong 1 and Shuang Zhao 1 1 Department of Experimental Oncology and Animal Center, Shengjing Hospital of China Medical University, Shenyang 110004, China Correspondence to: Hua-Chuan Zheng, email: zheng_huachuan@hotmail.com Keywords: GRP78, gastric cancer, meta analysis, bioinformatics analysis Received: July 05, 2017 Accepted: August 04, 2017 Published: August 18, 2017 ABSTRACT GRP78 is a molecular chaperone located in endoplasmic reticulum, and induces folding and assembly of newly-synthesized proteins, proteasome degradation of aberrant proteins, and translocation of secretory proteins, autophagy, and epithelial-mesenchymal transition. We performed a systematic meta- and bioinformatics analysis through multiple online databases up to March 14, 2017. It was found that up-regulated GRP78 expression in gastric cancer, compared with normal mucosa at both protein and mRNA levels ( p < 0.05). GRP78 expression was positively correlated with depth of invasion, TNM staging and dedifferentiation of gastric cancer ( p < 0.05), while its mRNA expression was negatively correlated with depth of invasion, histological grading and dedifferentiation ( p < 0.05). A positive association between GRP78 expression and unfavorable overall survival was found in patients with gastric cancer ( p < 0.005). A higher GRP78 mRNA expression was positively correlated with overall and progression-free survival rates of all cancer patients, even stratified by aggressive parameters, or as an independent factor ( p < 0.05). These findings indicated that GRP78 expression might be employed as a potential marker to indicate gastric carcinogenesis and subsequent progression, even prognosis. |
| Databáze: | OpenAIRE |
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