Applying standardized uptake values in gallium-67-citrate single-photon emission computed tomography/computed tomography studies and their correlation with blood test results in representative organs
| Autor: | Ukihide Tateishi, Akihiro Yamaguchi, Jun Isogai, Hiromitsu Daisaki, Akira Toriihara, Katsuya Yoshida |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Materials science Single Photon Emission Computed Tomography Computed Tomography Computed tomography Standardized uptake value Gallium Gallium Radioisotopes Single-photon emission computed tomography 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Blood test Humans Radiology Nuclear Medicine and imaging Citrates Aged Retrospective Studies medicine.diagnostic_test business.industry Phantoms Imaging Biological Transport General Medicine Reference Standards 030220 oncology & carcinogenesis Female Gallium 67 citrate Nuclear medicine business Semi quantitative Emission computed tomography Blood Chemical Analysis |
| Zdroj: | Nuclear medicine communications. 39(8) |
| ISSN: | 1473-5628 |
| Popis: | Recently, semiquantitative analysis using standardized uptake value (SUV) has been introduced in bone single-photon emission computed tomography/computed tomography (SPECT/CT). Our purposes were to apply SUV-based semiquantitative analytic method for gallium-67 (Ga)-citrate SPECT/CT and to evaluate correlation between SUV of physiological uptake and blood test results in representative organs.The accuracy of semiquantitative method was validated using an National Electrical Manufacturers Association body phantom study (radioactivity ratio of sphere : background=4 : 1). Thereafter, 59 patients (34 male and 25 female; mean age, 66.9 years) who had undergone Ga-citrate SPECT/CT were retrospectively enrolled in the study. A mean SUV of physiological uptake was calculated for the following organs: the lungs, right atrium, liver, kidneys, spleen, gluteal muscles, and bone marrow. The correlation between physiological uptakes and blood test results was evaluated using Pearson's correlation coefficient.The phantom study revealed only 1% error between theoretical and actual SUVs in the background, suggesting the sufficient accuracy of scatter and attenuation corrections. However, a partial volume effect could not be overlooked, particularly in small spheres with a diameter of less than 28 mm. The highest mean SUV was observed in the liver (range: 0.44-4.64), followed by bone marrow (range: 0.33-3.60), spleen (range: 0.52-2.12), and kidneys (range: 0.42-1.45). There was no significant correlation between hepatic uptake and liver function, renal uptake and renal function, or bone marrow uptake and blood cell count (P0.05).The physiological uptake in Ga-citrate SPECT/CT can be represented as SUVs, which are not significantly correlated with corresponding blood test results. |
| Databáze: | OpenAIRE |
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