A Useful Combination of Quantitative Ultrashort Echo Time MR Imaging and a Probing Device for Biomechanical Evaluation of Articular Cartilage
| Autor: | Masaru Teramoto, Jiang Du, Saeed Jerban, Erik W. Dorthe, Darryl D. D'Lima, Eric Y. Chang, Yanjun Chen, Takehito Hananouchi, Yajun Ma |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cartilage
Articular Materials science quantitative magnetic resonance imaging lcsh:Biotechnology Clinical Biochemistry Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Elastic Modulus lcsh:TP248.13-248.65 medicine Humans articular cartilage Magnetization transfer Elastic modulus 030222 orthopedics medicine.diagnostic_test Cartilage Stiffness Magnetic resonance imaging General Medicine probing device Horizontal plane Magnetic Resonance Imaging Biomechanical Phenomena mechanical property Tilt (optics) medicine.anatomical_structure Reaction medicine.symptom human activities Biomedical engineering |
| Zdroj: | Biosensors, Vol 11, Iss 52, p 52 (2021) Biosensors Volume 11 Issue 2 |
| ISSN: | 2079-6374 |
| Popis: | In this study, we combined quantitative ultrashort echo time (UTE) magnetic resonance (MR) imaging and an investigation by a probing device with tri-axial force sensor to seek correlations with mechanical properties of human patellar cartilage for in situ evaluation of biomechanical properties. Cartilage blocks (15 × 20 × 5 mm3) were dissected from the patella of six donors 5 mm square regions of interest from the cartilage blocks were imaged using UTE-MR imaging sequences (T2* and magnetization transfer ratio (MTR)), and mechanical properties were measured using a micro indentation device. Then, the vertical reaction force on the cartilage surface was measured while push-probing forward 3 mm with the probing device at a 30° tilt to the horizontal plane. The results showed a positive correlation between stiffness/elastic modulus and each predictor variable (UTE-T2* (r = 0.240 and 0.255, respectively, UTE-MTR (r = 0.378 and 0.379, respectively), and probing device force (r = 0.426 and 0.423, respectively). Furthermore, multiple linear regression analysis showed the combination of the three predictors had stronger correlation (adjusted r2 = 0.314 (stiffness), 0.323 (elastic), respectively). Our results demonstrate the potential for these non- and less- invasive methods for in situ evaluation of the mechanical properties of cartilage tissue. |
| Databáze: | OpenAIRE |
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