Melanoma Prevention: Comparison of Different Screening Methods for the Selection of a High Risk Population
| Autor: | Pietro Massei, Grazia Salimbeni, Andrea Nannipieri, Nevio Dubbini, Maurizia Ghilardi, Marco Celli, Stefano Malloggi, Giovanni Menchini, Laura Ricci, Tommaso Rubino, Antonella Romanini, Roberto Gianfaldoni, Giuseppe Ferraùto, Antonella Puddu, Daniele Gandini, Serena Gianfaldoni |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Health Toxicology and Mutagenesis Population lcsh:Medicine Article 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Screening method melanoma Medicine Humans Mass Screening 030212 general & internal medicine Family history education Physical Examination Selection (genetic algorithm) Secondary prevention education.field_of_study business.industry Melanoma screening lcsh:R Public Health Environmental and Occupational Health Limiting medicine.disease Risk evaluation 030220 oncology & carcinogenesis Female business secondary prevention |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 18, Iss 1953, p 1953 (2021) Volume 18 Issue 4 |
| ISSN: | 1660-4601 1661-7827 |
| Popis: | Background: Guidelines recommend limiting melanoma screening in a population with known risk factors, but none indicates methods for efficient recruitment. The purpose of this study is to compare three different methods of recruiting subjects to be screened for melanoma to detect which, if any, is the most efficient. Methods: From 2010 to 2019, subjects were recruited as follows: (1) regular skin examinations (RS), mainly conducted through the Associazione Contro il Melanoma network (2) occasional melanoma screening (OS), during annual public campaigns (3) and selective screening (SS), where people were invited to undergo a skin check after filling in a risk evaluation questionnaire, in cases where the assigned outcome was intermediate/high risk. Melanoma risk factors were compared across different screening methods. Generalized Linear Mixed Models were used for multivariable analysis. Results: A total of 2238 subjects (62.7% women) were recruited, median age 44 years (2–85), and 1094 (48.9 %) records were collected through RS, 826 (36.9 %) through OS, and 318 (14.2 %) through SS. A total of 131 suspicious non-melanoma skin cancers were clinically diagnosed, 20 pathologically confirmed, and 2 melanomas detected. SS performed significantly better at selecting subjects with a family history of melanoma and I-II phototypes compared to OS. Conclusions: Prior evaluation of melanoma known risk factors allowed for effective selection of a population to screen at higher risk of developing a melanoma. |
| Databáze: | OpenAIRE |
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