Effect of a Topical Gel Based on Adelmidrol + Trans-Traumatic Acid in the Treatment of Diabetic Foot Ulcers: An Open-Label Study
| Autor: | Fiorenza Grandi, Fabrizia Perrone, Alessandro Mantovani, Ilaria Teobaldi, Patrizia Piccagli, Barbara Baldo, Vincenzo Stoico |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Necrosis Palmitic Acids Fibrin chemistry.chemical_compound Traumatic acid Diabetes mellitus Diabetes Mellitus Humans Medicine Dicarboxylic Acids Adverse effect Foot Ulcer Wound Healing biology business.industry Adelmidrol Granulation tissue General Medicine medicine.disease Diabetic foot Dermatology Diabetic Foot medicine.anatomical_structure chemistry biology.protein medicine.symptom business |
| Zdroj: | Journal of the American Podiatric Medical Association. 112 |
| ISSN: | 8750-7315 |
| Popis: | Background: Diabetic foot ulceration is a severe complication of diabetes characterized by chronic inflammation and impaired wound healing. This study aimed to evaluate the effect of a medical device gel based on adelmidrol + trans-traumatic acid in the healing process of diabetic foot ulcers. Methods: Thirty-seven diabetic patients with foot ulcers of mild/moderate grade were treated with the gel daily for 4 weeks on the affected area. The following parameters were evaluated at baseline and weekly: 1) wound area, measured by drawing a map of the ulcer and then calculated with photo editing software tools, and 2) clinical appearance of the ulcer, assessed by recording the presence/absence of dry/wet necrosis, infection, fibrin, neoepithelium, exudate, redness, and granulation tissue. Results: Topical treatment led to progressive healing of diabetic foot ulcers with a significant reduction of the wound area and an improvement in the clinical appearance of the ulcers. No treatment-related adverse events were observed. Conclusions: The results of this open-label study show the potential benefits of adelmidrol + trans-traumatic acid topical administration to promote reepithelialization of diabetic foot ulcers. Further studies are needed to confirm the observed results. |
| Databáze: | OpenAIRE |
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