Identification of new genetic risk factors for prostate cancer
| Autor: | Rosemary A. Wilkinson, Michelle Guy, Melisa Bagnato, David E. Neal, Colin Cooper, Amanda L. Hall, Zsofia Kote-Jarai, Charles Jameson, Sarah Jugurnauth, Sameer Jhavar, Vincent Khoo, Kenneth Muir, Dallas R. English, Cyril Fisher, Gianluca Severi, Audrey Ardern-Jones, Lynne T. O'Brien, Daniel Leongamornlert, Alan Horwich, Angela Cox, Sarah L Bryant, Helen I. Field, Ali Amin Al Olama, Tim Christmas, Artitaya Lophatananon, Douglas F. Easton, Rosalind A. Eeles, Malgorzata Tymrakiewicz, David P. Dearnaley, Graham G. Giles, Robert Huddart, Charmaine Smith, Jenny L Donovan, Sarah J Lewis, Chris Parker, Paul M. Brown, Melissa C. Southey, Jonathan J. Morrison, Shani Mulholland, Freddie C. Hamdy, Stephen M. Edwards, Alan Thompson, Beatrice N. Gehr-Swain, Chris Ogden, C. R. J. Woodhouse, John L. Hopper |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Urology Single-nucleotide polymorphism Genome-wide association study Computational biology Review Protein Serine-Threonine Kinases Prostate cancer Risk Factors Genetic predisposition Medicine Humans MSMB Genetic Predisposition to Disease Genetic Testing Genetic testing Genetic association Genetics medicine.diagnostic_test business.industry Membrane Proteins Prostatic Neoplasms Prostatic Secretory Proteins General Medicine medicine.disease Penetrance Kallikreins business |
| Zdroj: | Asian journal of andrology. 11(1) |
| ISSN: | 1745-7262 1008-682X |
| Popis: | There is evidence that a substantial part of genetic predisposition to prostate cancer (PCa) may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare. |
| Databáze: | OpenAIRE |
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