Evidence after imputation for a role of MICA variants in nonprogression and elite control of HIV type 1 infection
| Autor: | Sigrid Le Clerc, Vincent Laville, Taoufik Labib, Jean-Louis Spadoni, François Schächter, Jean-François Zagury, Cédric Coulonges, Josselin Noirel, Sophie Caillat-Zucman, Damien Ulveling, Olivier Delaneau, Matthieu Montes |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Linkage disequilibrium RNA Untranslated Genome-wide association study Single-nucleotide polymorphism HIV Infections Biology Polymorphism Single Nucleotide Linkage Disequilibrium Cohort Studies Major Histocompatibility Complex Young Adult Immunology and Allergy Humans 1000 Genomes Project Genetic Association Studies Genetic association Disease Resistance Genetics HCP5 Haplotype Histocompatibility Antigens Class I Middle Aged Virology Infectious Diseases Haplotypes HIV-1 Female RNA Long Noncoding Imputation (genetics) |
| Zdroj: | The Journal of infectious diseases. 210(12) |
| ISSN: | 1537-6613 |
| Popis: | Past genome-wide association studies (GWAS) involving individuals with AIDS have mainly identified associations in the HLA region. Using the latest software, we imputed 7 million single-nucleotide polymorphisms (SNPs)/indels of the 1000 Genomes Project from the GWAS-determined genotypes of individuals in the Genomics of Resistance to Immunodeficiency Virus AIDS nonprogression cohort and compared them with those of control cohorts. The strongest signals were in MICA, the gene encoding major histocompatibility class I polypeptide-related sequence A (P = 3.31 × 10(-12)), with a particular exonic deletion (P = 1.59 × 10(-8)) in full linkage disequilibrium with the reference HCP5 rs2395029 SNP. Haplotype analysis also revealed an additive effect between HLA-C, HLA-B, and MICA variants. These data suggest a role for MICA in progression and elite control of human immunodeficiency virus type 1 infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|