Comparative efficacy of vasoconstrictor therapies for type 1 hepatorenal syndrome: a network meta-analysis
Autor: | Yi-Jing Han, Ming-Hua Zheng, Dan-Qin Sun, Tian-Tian Zou, Jian-Hong Zhong, Martin Braddock, Yu-Jie Zhou, Ji-Na Zheng |
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Rok vydání: | 2017 |
Předmět: |
Drug
Male medicine.medical_specialty Comparative Effectiveness Research Hepatorenal Syndrome media_common.quotation_subject Population Plasma Substitutes Lypressin law.invention Norepinephrine (medication) 03 medical and health sciences Norepinephrine 0302 clinical medicine Hepatorenal syndrome Randomized controlled trial law Risk Factors Internal medicine Albumins medicine Odds Ratio Humans Vasoconstrictor Agents 030212 general & internal medicine education media_common Randomized Controlled Trials as Topic education.field_of_study Hepatology business.industry Gastroenterology Middle Aged medicine.disease Surgery Indirect comparison Treatment Outcome Vasoconstriction Meta-analysis 030211 gastroenterology & hepatology Female Terlipressin business medicine.drug |
Zdroj: | Expert review of gastroenterologyhepatology. 11(11) |
ISSN: | 1747-4132 |
Popis: | The outcome of a comparative efficacy and safety of vasoconstrictor therapies for treatment of patients with type 1 hepatorenal syndrome (HRS-1) remain inconclusive. Areas covered: We searched literature databases for randomized controlled trials (RCTs) until 31 January 2016, and included ten eligible RCTs. In conclusion, terlipressin was the most efficacious vasoconstrictor drug for HRS-1, but had a higher probability of causing AEs. Norepinephrine was an attractive alternative to terlipressin and associated with less AEs. Expert commentary: To date, most previous traditional meta-analyses included trials with a limited population and compared terlipressin alone or with albumin against no intervention or albumin. Since different HRS types have different diagnoses and show different responses to vasoconstrictors, it may be questionable to combine data from patients with type 1 and type 2 HRS, which has been reported for most previous meta-analyses. Thus, performing a high-quality network meta-analysis of the existing literature is a valuable way to interrogate published data and to draw conclusions which may inform on the best interventional strategy. |
Databáze: | OpenAIRE |
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