GLP-1 expression in von Ebner's gland of diabetic rats
| Autor: | Xiao Yuan, Li-hong Zhou, Xiao-hong Feng, Dong Wang |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
endocrine system Taste medicine.medical_specialty Physiology Biology Biochemistry Streptozocin Diabetes Mellitus Experimental Cellular and Molecular Neuroscience Endocrinology stomatognathic system Glucagon-Like Peptide 1 Diabetes mellitus Internal medicine medicine Animals Glucose homeostasis Endocrine system Rats Wistar von Ebner Glands digestive oral and skin physiology Von Ebner's gland medicine.disease Glucagon-like peptide-1 Rats medicine.anatomical_structure Immunohistochemistry hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Peptides. 38:137-141 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/j.peptides.2012.09.002 |
| Popis: | GLP-1, a peptidergic endocrine hormone, which associate with appetite control, glucose homeostasis and satiety. It might play an important role in the gustatory system. We tried to investigate the expression of GLP-1 in von Ebner's gland of diabetic and control rats, and the ultrastructure changes on von Ebner's gland of diabetes rats. GLP-1 expression in von Ebner's gland was evaluated by immunohistochemistry. The number of GLP-1 positive cells in diabetic rat von Ebner's gland was significantly higher than that in normal controls. Electron micrographs showed that a series of pathologic changes in von Ebner's gland of diabetes rats. The results suggest that GLP-1 have some effects within the gustatory systems, and elevated von Ebner's gland GLP-1 expression may be one cause of diabetic taste impairment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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