Celecoxib treatment alters the gene expression profile of normal colonic mucosa

Autor: Casey Jo Humbyrd, Gary Gordon, Jean Jenkins, Steven Gallinger, Oleg K. Glebov, Aby Buchbinder, Luz Rodriguez, Henry T. Lynch, Ilan R. Kirsch, Kenneth Nakahara, Janet Cliatt, Patrick M. Lynch, John Denobile, Sherri Patterson, Peter W. Soballe, Ernest T. Hawk
Rok vydání: 2006
Předmět:
Zdroj: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 15(7)
ISSN: 1055-9965
Popis: A clinical trial was recently conducted to evaluate the safety and efficacy of a selective inhibitor of cyclooxygenase-2 (celecoxib) in hereditary nonpolyposis colon cancer patients. In a randomized, placebo-controlled phase I/II multicenter trial, hereditary nonpolyposis colon cancer patients and gene carriers received either celecoxib at one of two doses or placebo. The goal was to evaluate the effects of these treatment arms on a number of endoscopic and tissue-based biomarker end points after 12 months of treatment. As part of this trial, we analyzed gene expression by cDNA array technology in normal descending (rectal) colonic mucosa of patients before and after treatment with celecoxib or placebo. We found that treatment of patients with celecoxib at recommended clinical doses (200 and 400 mg p.o. bid), in contrast to treatment with placebo, leads to changes in expression of >1,400 genes in the healthy colon, although in general, the magnitude of changes is
Databáze: OpenAIRE