Celecoxib treatment alters the gene expression profile of normal colonic mucosa
Autor: | Casey Jo Humbyrd, Gary Gordon, Jean Jenkins, Steven Gallinger, Oleg K. Glebov, Aby Buchbinder, Luz Rodriguez, Henry T. Lynch, Ilan R. Kirsch, Kenneth Nakahara, Janet Cliatt, Patrick M. Lynch, John Denobile, Sherri Patterson, Peter W. Soballe, Ernest T. Hawk |
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Rok vydání: | 2006 |
Předmět: |
Epidemiology
Colorectal cancer Colon medicine.medical_treatment Gene Expression Placebos Multicenter trial Gene expression medicine Humans Cyclooxygenase Inhibitors Intestinal Mucosa skin and connective tissue diseases Oligonucleotide Array Sequence Analysis Sulfonamides business.industry Reverse Transcriptase Polymerase Chain Reaction Gene Expression Profiling medicine.disease Gene expression profiling Cytokine Oncology Celecoxib Immunology Cancer research Biomarker (medicine) Pyrazoles business Colorectal Neoplasms Biomarkers medicine.drug Transforming growth factor |
Zdroj: | Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 15(7) |
ISSN: | 1055-9965 |
Popis: | A clinical trial was recently conducted to evaluate the safety and efficacy of a selective inhibitor of cyclooxygenase-2 (celecoxib) in hereditary nonpolyposis colon cancer patients. In a randomized, placebo-controlled phase I/II multicenter trial, hereditary nonpolyposis colon cancer patients and gene carriers received either celecoxib at one of two doses or placebo. The goal was to evaluate the effects of these treatment arms on a number of endoscopic and tissue-based biomarker end points after 12 months of treatment. As part of this trial, we analyzed gene expression by cDNA array technology in normal descending (rectal) colonic mucosa of patients before and after treatment with celecoxib or placebo. We found that treatment of patients with celecoxib at recommended clinical doses (200 and 400 mg p.o. bid), in contrast to treatment with placebo, leads to changes in expression of >1,400 genes in the healthy colon, although in general, the magnitude of changes is |
Databáze: | OpenAIRE |
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