Quantitative 18F-fluorodeoxyglucose positron emission tomography/computed tomography to assess pulmonary inflammation in COPD
| Autor: | Laurence Vass, Divya Mohan, Ruth Tal-Singer, Kaisa M. Mäki-Petäjä, Julia R. Forman, Jonathan Fuld, Marie Fisk, John R. Cockcroft, Anand Devaraj, Nicholas S Hopkinson, Ian B. Wilkinson, Carmel M. McEniery, Joseph Cheriyan, Adelola Oseni, Michael I. Polkey, David A. Lomas |
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| Přispěvatelé: | Mohan, Divya [0000-0001-9153-2683], Hopkinson, Nicholas S [0000-0003-3235-0454], Tal-Singer, Ruth [0000-0002-5275-8062], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Imaging biomarker Chronic Obstructive Pulmonary Disease Respiratory System 32 Biomedical and Clinical Sciences Inflammation Computed tomography EMPHYSEMA Fibrinogen Gastroenterology DISEASE Clinical Research Original Research Articles Internal medicine Tobacco medicine COPD BIOSYNTHESIS 3202 Clinical Sciences Lung FIBRINOGEN Science & Technology Tobacco Smoke and Health medicine.diagnostic_test STATEMENT business.industry Prevention Pulmonary inflammation medicine.disease respiratory tract diseases PET medicine.anatomical_structure Positron emission tomography CELLS Respiratory Biomedical Imaging Medicine medicine.symptom business Life Sciences & Biomedicine medicine.drug |
| Zdroj: | ERJ Open Research, Vol 7, Iss 3 (2021) ERJ Open Research article-version (VoR) Version of Record |
| ISSN: | 2312-0541 |
| Popis: | Rationale COPD and smoking are characterised by pulmonary inflammation. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging may improve knowledge of pulmonary inflammation in COPD patients and aid early development of novel therapies as an imaging biomarker. Objectives To evaluate pulmonary inflammation, assessed by FDG uptake, in whole and regional lung in “usual” (smoking-related) COPD patients, alpha-1 antitrypsin deficiency (α1ATD) COPD patients, smokers without COPD and never-smokers using FDG PET/CT. Secondly, to explore cross-sectional associations between FDG PET/CT and systemic inflammatory markers in COPD patients and repeatability of the technique in COPD patients. Methods Data from two imaging studies were evaluated. Pulmonary FDG uptake (normalised Ki; nKi) was measured by Patlak graphical analysis in four subject groups: 84 COPD patients, 11 α1ATD-COPD patients, 12 smokers and 10 never-smokers. Within the COPD group, associations between nKi and systemic markers of inflammation were assessed. Repeatability was evaluated in 32 COPD patients comparing nKi values at baseline and at 4-month follow-up. Results COPD patients, α1ATD-COPD patients and smokers had increased whole lung FDG uptake (nKi) compared with never-smokers (0.0037±0.001, 0.0040±0.001, 0.0040±0.001 versus 0.0028±0.001 mL·cm−3·min−1, respectively, p FDG PET/CT has potential utility to noninvasively evaluate pulmonary inflammation in COPD. Pulmonary FDG uptake is increased in COPD patients, positively associated with systemic inflammatory markers and shows low inter-occasion variability. https://bit.ly/3dELYAW |
| Databáze: | OpenAIRE |
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