Prospects of Radioimmunotherapy in Epithelial Ovarian Cancer: Results with Iodine-131-Labeled Murine and Humanized MN-14 Anti-carcinoembryonic Antigen Monoclonal Antibodies
| Autor: | Lawrence C. Swayne, David M. Goldenberg, Malik E. Juweid, Robert M. Sharkey, Robert M. Dunn, Thomas Herskovic, Arnold D. Rubin |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Pathology medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Antibodies Monoclonal Humanized Scintigraphy Gastroenterology Drug Administration Schedule Iodine Radioisotopes Mice Route of administration Carcinoembryonic antigen Internal medicine medicine Carcinoma Animals Humans Infusions Intravenous Aged Aged 80 and over Ovarian Neoplasms Leukopenia medicine.diagnostic_test biology business.industry Antibodies Monoclonal Obstetrics and Gynecology Middle Aged Radioimmunotherapy medicine.disease Carcinoembryonic Antigen Radiation therapy Treatment Outcome Oncology Toxicity biology.protein Female medicine.symptom business |
| Zdroj: | Gynecologic Oncology. 67:259-271 |
| ISSN: | 0090-8258 |
| Popis: | Objectives. Epithelial ovarian cancer (EOC) is known to produce carcinoembryonic antigen (CEA), and the plasma CEA level is frequently elevated in patients with advanced stage and bulk of tumor. This study reports the results of a phase I therapy trial with intravenously administered 131 I-MN-14 anti-CEA monoclonal antibody (MAb) in patients with EOC. Methods. Fourteen patients with advanced refractory EOC were given escalating intravenous doses (two received 30 mCi/m 2 , six 40 mCi/m 2 , and six 50 mCi/m 2 ) of 131 I-MN-14 IgG. All patients received a diagnostic study with 8 mCi (0.6 mg) of 131 I-MN-14 IgG 1 week prior to their therapy infusion. Tumor targeting was assessed by external scintigraphy, toxicity according to the Radiation Therapy Oncology Group criteria, and therapy responses by CT and serum CA-125. Results. The MAb scan was positive in all 14 treated patients. Myelosuppression was the only observed treatment-related toxicity. Dose-limiting toxicity, defined as grade 4 leukopenia or thrombocytopenia of any duration, or grade 3 leukopenia or thrombocytopenia of >2 weeks, was not seen at the 30 or 40 mCi/m 2 dose levels. However, 2 of 6 patients treated at 50 mCi/m 2 had a grade 4 thrombocytopenia or a grade 3 thrombocytopenia lasting 18 days. Of the 14 patients, 1 with diffuse peritoneal implants of ≤2 cm had a complete clinical remission by CT and CA-125 for 8 months, following an initial partial remission for 10 months, both at the 40 mCi/m 2 dose level. Another patient had a mixed response for 1 month. Conclusion. MN-14 anti-CEA MAb is a suitable agent for tumor targeting and may have a therapeutic potential in patients with chemotherapy-refractive EOC, especially those with minimal disease. |
| Databáze: | OpenAIRE |
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