Lymnaea stagnalis as model for translational neuroscience research: from pond to bench
| Autor: | Chiara Colliva, Cristina Benatti, Veronica Rivi, Nicoletta Brunello, Fabio Tascedda, G. Radighieri, Johanna Maria Catharina Blom |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Aging
behavioural test snails Cognitive Neuroscience Lymnaea stagnalis Model system Translational Research Biomedical memory Behavioral Neuroscience stress translational medicine Memory aging Animals Lymnaea Cognitive science Memory Disorders biology Neurosciences Translational medicine Classical conditioning biology.organism_classification Neuropsychology and Physiological Psychology Innovative Therapies Models Animal Psychology Stress Psychological Translational neuroscience |
| Popis: | The purpose of this review is to illustrate how a reductionistic, but sophisticated, approach based on the use of a simple model system such as the pond snail Lymnaea stagnalis (L. stagnalis), might be useful to address fundamental questions in learning and memory. L. stagnalis, as a model, provides an interesting platform to investigate the dialog between the synapse and the nucleus and vice versa during memory and learning. More importantly, the “molecular actors” of the memory dialogue are well-conserved both across phylogenetic groups and learning paradigms, involving single- or multi-trials, aversion or reward, operant or classical conditioning. At the same time, this model could help to study how, where and when the memory dialog is impaired in stressful conditions and during aging and neurodegeneration in humans and thus offers new insights and targets in order to develop innovative therapies and technology for the treatment of a range of neurological and neurodegenerative disorders. |
| Databáze: | OpenAIRE |
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