The association between birthweight and longevity in the rat is complex and modulated by maternal protein intake during fetal life
| Autor: | Dean V. Sculley, Simon C. Langley-Evans |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Offspring media_common.quotation_subject Longevity Biophysics Physiology Biology Biochemistry Fetal Development Structural Biology Pregnancy Internal medicine Fetal programming Genetics medicine Animals Birth Weight Protein restriction Rats Wistar Molecular Biology media_common Fetus Fetal Growth Retardation Malnutrition Cell Biology medicine.disease Rats Endocrinology Ageing Rat Gestation Female Dietary Proteins |
| Zdroj: | FEBS letters. 580(17) |
| ISSN: | 0014-5793 |
| Popis: | Maternal protein restriction in rat pregnancy has been suggested to reduce lifespan of the resulting offspring by inducing fetal growth retardation, followed by postnatal catch-up growth. We tested the hypothesis that lifespan could be programmed in both males and females by exposure to undernutrition at specific stages of fetal development. Protein restriction throughout gestation significantly reduced lifespan in both males and females. Low birthweight increased longevity, whilst rapid postnatal growth had a detrimental effect. There was no evidence that undernutrition programmed lifespan through oxidative processes in the major organs. Fetal programming is an important contributor to the ageing process. |
| Databáze: | OpenAIRE |
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