Severity of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus: Relationship between Nongenetic Factors and PNPLA3/HSD17B13 Polymorphisms
| Autor: | Venkata Ramana Mallela, Livia Salmi, Rosalba Minisini, Mattia Bellan, C. Colletta, Giuseppe Saglietti, Gian Piero Carnevale Schianca, Luigi Mario Castello, Mario Pirisi, Matteo Nazzareno Barbaglia, Roberto Clerici |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences Liver disease 0302 clinical medicine Polymorphism (computer science) Diabetes mellitus Internal medicine Nonalcoholic fatty liver disease Genetics medicine Adiponutrin education Body mass index education.field_of_study business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus Diabetes mellitus type 2 medicine.disease Fibrosis Original Article Transient elastography business Non-alcoholic fatty liver disease |
| Zdroj: | Diabetes & Metabolism Journal |
| ISSN: | 2233-6087 2233-6079 |
| DOI: | 10.4093/dmj.2018.0201 |
| Popis: | Background The prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM) is high, though its severity is often underestimated. Our aim is to provide an estimate of the prevalence of severe NAFLD in T2DM and identify its major predictors. Methods T2DM patients (n=328) not previously known to have NAFLD underwent clinical assessment, transient elastography with measure of liver stiffness (LS) and controlled attenuation parameter (CAP), and genotyping for patatin like phospholipase domain containing 3 (PNPLA3) and 17β-hydroxysteroid-dehydrogenase type 13 (HSD17B13). Results Median LS was 6.1 kPa (4.9 to 8.6). More than one-fourth patients had advanced liver disease, defined as LS ≥7.9 kPa (n=94/238, 29%), and had a higher body mass index (BMI) than those with a LS |
| Databáze: | OpenAIRE |
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