Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia
| Autor: | Paul R. Kinchington, Anton W. Langerak, Johannes C M Milikan, Georges M. G. M. Verjans, Albert D. M. E. Osterhaus, Angelique Poot, Jessica M. van Dun, Jon D. Laman, Rogier Q. Hintzen |
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| Přispěvatelé: | Virology, Neurology, Rehabilitation Medicine, Immunology |
| Rok vydání: | 2007 |
| Předmět: |
Herpesvirus 3
Human viruses T cell Herpesvirus 1 Human CD8-Positive T-Lymphocytes Biology medicine.disease_cause Granzymes Immunoenzyme Techniques Latent Virus medicine Humans Receptor Multidisciplinary Effector Varicella zoster virus Antibodies Monoclonal Herpesviridae Infections Biological Sciences Virology Virus Latency Granzyme B medicine.anatomical_structure Herpes simplex virus Trigeminal Ganglion CD8 |
| Zdroj: | Proceedings of the National Academy of Sciences of the U.S.A., 104(9), 3496-3501. National Academy of Sciences |
| ISSN: | 0027-8424 |
| Popis: | Primary infection with herpes simplex virus 1 (HSV-1) and varicella zoster virus (VZV) results in lifelong latent infections of neurons in sensory ganglia such as the trigeminal ganglia (TG). It has been postulated that T cells retained in TG inhibit reactivation of latent virus. The acquisition of TG specimens of individuals within hours after death offered the unique opportunity to characterize the phenotype and specificity of TG-resident T cells in humans. High numbers of activated CD8 + T cells expressing a late effector memory phenotype were found to reside in latently infected TG. The T cell infiltrate was oligoclonal, and T cells selectively clustered around HSV-1 but not VZV latently infected neurons. Neuronal damage was not observed despite granzyme B expression by the neuron-interacting CD8 + T cells. The TG-resident T cells, mainly CD8 + T cells, were directed against HSV-1 and not to VZV, despite neuronal expression of VZV proteins. The results implicate that herpesvirus latency in human TG is associated with a local, persistent T cell response, comprising activated late effector memory CD8 + T cells that appear to control HSV-1 latency by noncytolytic pathways. In contrast, T cells do not seem to be directly involved in controlling VZV latency in human TG. |
| Databáze: | OpenAIRE |
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