Key Aspects of the Novartis Compound Collection Enhancement Project for the Compilation of a Comprehensive Chemogenomics Drug Discovery Screening Collection
Autor: | Ansgar Schuffenhauer, Ulrich Schopfer, Juergen Hinrichs, Caroline Engeloch, Benjamin Havill, Hans-Joerg Roth, Pierre Acklin, Friederike Stoll, Guido Koch, Edgar Jacoby, Pascal Rigollier, Maxim Popov, David Orain, Peter Meier, Kamal Azzaoui, Rudolf K. A. Giger, Juerg Zimmermann, Jaroslav Stanek, Karine Malagu |
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Rok vydání: | 2005 |
Předmět: |
Combinatorial Chemistry Techniques
Computer science Drug discovery Drug Evaluation Preclinical Druggability Compound management Genomics General Medicine computer.software_genre Data science chemistry.chemical_compound chemistry Artificial Intelligence Peptide Library Drug Design Drug Discovery Key (cryptography) Chemogenomics Animals Humans Data mining computer |
Zdroj: | Current Topics in Medicinal Chemistry. 5:397-411 |
ISSN: | 1568-0266 |
Popis: | The NIBR (Novartis Institutes for BioMedical Research) compound collection enrichment and enhancement project integrates corporate internal combinatorial compound synthesis and external compound acquisition activities in order to build up a comprehensive screening collection for a modern drug discovery organization. The main purpose of the screening collection is to supply the Novartis drug discovery pipeline with hit-to-lead compounds for today's and the future's portfolio of drug discovery programs, and to provide tool compounds for the chemogenomics investigation of novel biological pathways and circuits. As such, it integrates designed focused and diversity-based compound sets from the synthetic and natural paradigms able to cope with druggable and currently deemed undruggable targets and molecular interaction modes. Herein, we will summarize together with new trends published in the literature, scientific challenges faced and key approaches taken at NIBR to match the chemical and biological spaces. |
Databáze: | OpenAIRE |
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