A cross-sectional study exploring useful indicators for low bone mineral density in male alcoholic patients
| Autor: | Tatsuhiro So, Noriaki Okishio, Akitoyo Hishimoto, Kentaro Mouri, Ikuo Otsuka, Naofumi Shimmyo, Tadasu Horai, Shuken Boku, Ichiro Sora |
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| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Neuropsychiatric Disease and Treatment hypertension Cross-sectional study media_common.quotation_subject alcohol dependence Population Osteoporosis 030209 endocrinology & metabolism smoking Bone remodeling 03 medical and health sciences 0302 clinical medicine tartrate-resistant acid phosphatase-5b Internal medicine medicine 030212 general & internal medicine education media_common Original Research Bone mineral education.field_of_study business.industry musculoskeletal neural and ocular physiology Abstinence medicine.disease musculoskeletal system Osteopenia osteopenia undercarboxylated osteocalcin business Body mass index |
| Zdroj: | Neuropsychiatric Disease and Treatment |
| ISSN: | 1176-6328 |
| Popis: | Tadasu Horai,1 Akitoyo Hishimoto,1 Ikuo Otsuka,1 Tatsuhiro So,2 Kentaro Mouri,1 Naofumi Shimmyo,1 Shuken Boku,1 Noriaki Okishio,3 Ichiro Sora1 1Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan; 2So Mental Clinic, Kobe, Japan; 3Hyogo Mental Health Center, Kobe, Japan Background: Alcohol dependence induces low bone mineral density (BMD), predicting osteoporosis, while low and moderate alcohol consumption may even increase BMD. In recent years, undercarboxylated osteocalcin (ucOC) and tartrate-resistant acid phosphatase-5b (TRACP-5b), bone turnover markers, have gained special interest as useful indicators of low BMD. However, it remains unclear whether other alcohol-related variables (eg, duration of abstinence and continuous drinking) are linked to aberrant BMD. In addition, no previous study has investigated whether ucOC or TRACP-5b is clinically useful to predict low BMD not only in the general population, but also in alcohol-dependent subjects.Patients and methods: We recruited 275 male alcohol-dependent subjects and collected information about their drinking habits, comorbid diseases, smoking history and walking exercise behavior. BMD in each subject was determined by ultrasonography. Serum liver enzymes (AST, ALT, ALP, ChE, γ-GTP and LDH), ucOC and TRACP-5b were measured in all subjects. T-scores were calculated according to BMD for all subjects.Results: The mean T-scores of our subjects were negatively shifted compared to the general population (-0.75±1.36 SD). We divided our subjects into a normal BMD group (n=137) and a low BMD group (n=138) according to their T-scores (T-score ≥-1 SD, normal BMD; T-score |
| Databáze: | OpenAIRE |
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