Genetic improvement of hip-extended scores in 3 breeds of guide dogs using estimated breeding values: Notable progress but more improvement is needed

Autor:	Thomas P. Gregor, Dolores Holle, Mischa B. McDonald-Lynch, Jennifer K. Reagan, Gail K. Smith, Eldin A. Leighton, Darryl N. Biery, Mandy L. Wallace
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Male Heredity Canine hip dysplasia Breeding Hip dysplasia (canine) 0403 veterinary science Skeletal Joints Medicine and Health Sciences Medicine Hip Dysplasia Canine Musculoskeletal System Mammals 0303 health sciences Multidisciplinary Pets and Companion Animals Eukaryota Inherited Metabolic Disorders 04 agricultural and veterinary sciences Phenotypes Genetic Diseases Vertebrates Female Glycogen Storage Diseases Anatomy Research Article Joint Instability medicine.medical_specialty 040301 veterinary sciences Animal Types Science Pelvis 03 medical and health sciences Dogs Autosomal Recessive Diseases Rheumatology Internal medicine Osteoarthritis Genetics Animals Canine genetics 030304 developmental biology Clinical Genetics Hip business.industry Arthritis Organisms Biology and Life Sciences Heritability First generation Metabolic Disorders Amniotes Genetic selection business Zoology
Zdroj:	PLoS ONE, Vol 14, Iss 2, p e0212544 (2019) PLoS ONE
ISSN:	1932-6203
Popis:	Two hip quality phenotypes-a hip-extended score assigned by a board certified radiologist and the PennHIP distraction index-were analyzed to estimate genetic parameters and to calculate estimated breeding values used for selecting replacement breeders. Radiographs obtained at 12-18 months of age were available on 5,201 German Shepherd Dogs, 4,987 Labrador Retrievers and 2,308 Golden Retrievers. Obtained by fitting a two-trait model using Bayesian techniques, estimates of heritability for the hip-extended score were 0.76, 0.72, and 0.41 in German Shepherd Dogs, Labrador Retrievers, and Golden Retrievers, respectively, while estimated heritabilities for distraction index were 0.60, 0.66 and 0.59, respectively. Genetic correlations between the two hip quality measures were -0.28 in German Shepherd Dogs, -0.21 in Labrador Retrievers, and -0.29 in Golden Retrievers. Genetic selection for improved hip quality based upon the hip extended score phenotype began in 1980. Among first generation puppies, 34% of 273 German Shepherd Dogs, 55% of 323 Labrador Retrievers, and 43% of 51 Golden Retrievers had an Excellent hip extended score. After 8 generations of selection, mostly based on estimated breeding values derived from the hip extended score, over 93% of 695 German Shepherd Dogs, 94% of 528 Labrador Retrievers, and 87% of 116 Golden Retrievers received an Excellent hip extended score. With respect to PennHIP distraction index values among these same dogs, median values were at or above 0.30 for all 3 breeds meaning that half or more of dogs possessing the Excellent hip-extended-score phenotype remained susceptible to developing the osteoarthritis of canine hip dysplasia. Genetic improvement of the hip-extended-view phenotype to its desired biological endpoint left a surprising proportion of dogs expressing sufficient joint laxity to place them in an osteoarthritis at-risk state as they age. Only by directly applying selection pressure to reduce distraction index was marked reduction in joint laxity noted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99765d6bf31d11bb9eecd6f5b0ba8fc3 https://doaj.org/article/14003efa44534ad9a9074b4d31a2624b Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.