Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study

Autor: Beatriz Gómez-Vicente, María Pedraza, Blanca Talavera, Isabel Hernández-Pérez, Enrique Martínez-Pías, Álvaro Sierra, Ángel L Guerrero, Javier Trigo, Álvaro Planchuelo-Gómez, Alba Chavarría-Miranda, David García-Azorín, Cristina López-Sanz, Gonzalo Valle-Peñacoba, Juan F. Arenillas, Elena Martínez-Velasco, Paula Simón-Campo, María Gutiérrez-Sánchez, Mercedes de Lera
Přispěvatelé: Garcia-Azorin, D. [0000-0002-3132-1064], Garcia-Azorin, D.
Rok vydání: 2020
Předmět:
Male
myalgia
Secondary
Multivariate analysis
lcsh:Medicine
0302 clinical medicine
Modified Rankin Scale
Risk of mortality
Hospital Mortality
030212 general & internal medicine
Aged
80 and over
Mortality rate
Headache
General Medicine
Middle Aged
Prognosis
Hospitalization
Survival Rate
Female
medicine.symptom
Coronavirus Infections
Research Article
medicine.medical_specialty
Pneumonia
Viral
Lower risk
Betacoronavirus
03 medical and health sciences
Internal medicine
Headache disorders
medicine
Humans
Mortality
Pandemics
Survival rate
Headache disorders
secondary
Aged
Retrospective Studies
SARS-CoV-2
business.industry
lcsh:R
COVID-19
Retrospective cohort study
Nervous system diseases
Mortality
laboratory parameters
Anesthesiology and Pain Medicine
Laboratory parameters
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: The Journal of Headache and Pain, Vol 21, Iss 1, Pp 1-10 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
The Journal of Headache and Pain
ISSN: 1129-2377
1129-2369
DOI: 10.1186/s10194-020-01165-8
Popis: Introduction: Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality. Methods: Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demographic data, clinical variables and laboratory abnormalities. We used multivariate regression analysis. Results: During the study period, 576 patients were included, aged 67.2 (SD: 14.7), and 250/576 (43.3%) being female. Presence of headache was described by 137 (23.7%) patients. The all-cause in-hospital mortality rate was 127/576 (20.0%). In the multivariate analysis, patients with headache had a lower risk of mortality (OR: 0.39, 95% CI: 0.17–0.88, p = 0.007). After adjusting for multiple comparisons in a multivariate analysis, variables that were independently associated with a higher odds of having headache in COVID-19 patients were anosmia, myalgia, female sex and fever; variables that were associated with a lower odds of having headache were younger age, lower score on modified Rankin scale, and, regarding laboratory variables on admission, increased C-reactive protein, abnormal platelet values, lymphopenia and increased D-dimer. Conclusion: Headache is a frequent symptom in COVID-19 patients and its presence is an independent predictor of lower risk of mortality in COVID-19 hospitalized patients.
Databáze: OpenAIRE
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