Microsatellite instability: impact on cancer progression in proximal and distal colorectal cancers
| Autor: | Pirkko Vihko, Tuomo J. Karttunen, Markus J. Mäkinen, Jyrki Mäkelä, Petra Jernvall |
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| Rok vydání: | 1999 |
| Předmět: |
Oncology
Adult Genetic Markers Male endocrine system Cancer Research medicine.medical_specialty Pathology Adolescent Colorectal cancer Rectum Biology Genes MCC law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine medicine Carcinoma Humans Child Polymerase chain reaction Survival analysis 030304 developmental biology Aged Aged 80 and over 0303 health sciences Analysis of Variance Rectal Neoplasms nutritional and metabolic diseases Cancer Microsatellite instability Middle Aged medicine.disease Prognosis Colorectal Neoplasms Hereditary Nonpolyposis Survival Analysis 3. Good health medicine.anatomical_structure Genetic marker 030220 oncology & carcinogenesis Colonic Neoplasms Female human activities Follow-Up Studies Microsatellite Repeats |
| Zdroj: | European journal of cancer (Oxford, England : 1990). 35(2) |
| ISSN: | 0959-8049 |
| Popis: | Whilst individual planning of treatment and follow-up in every colorectal cancer case is an increasing demand, prognostic markers are needed for predicting cancer progression in the primary phase. We studied the effect of replication error (RER)-positivity on colorectal cancer progression by analysing 255 colorectal cancer specimens by polymerase chain reaction (PCR) and fragment analysis and correlating the results with the clinical and histological features of the tumour and with patient outcome. RER-positivity was detected in 12% (28/235) of cases. It was associated with proximal location of the tumour (P < 0.001), poor differentiation (P = 0.001) and large tumour size (P = 0.009). The 5-year cumulative survival rate of the patients with RER-positive cancer of the proximal colon was markedly better (100%) than that of those with RER-negative proximal cancer (74%), whilst in cases of cancer of the distal colon or rectum, RER-positivity (21%) indicated poorer survival than RER-negativity (57%). Thus, it is suggested that RER-positivity has an opposite impact on cancer progression in cases of proximal and distal cancers. RER-positivity appears to indicate improved prognosis only in cases of proximally located cancer, in which it could accordingly be useful as a prognostic marker. |
| Databáze: | OpenAIRE |
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