Fast multigram scale microwave-assisted synthesis of vitamin E and C10-, C15-analogues under vacuum
| Autor: | Laura Rotolo, Diego Carnaroglio, Alessandro Barge, E. Calcio Gaudino, Silvia Tagliapietra, Giancarlo Cravotto |
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| Rok vydání: | 2016 |
| Předmět: |
ultrasound
010405 organic chemistry Chemistry General Chemical Engineering Condensation General Chemistry 010402 general chemistry alpha-tocopherol organic-chemistry catalysts d l-alpha-tocopherol ultrasound 01 natural sciences Combinatorial chemistry Evaporation (deposition) catalysts 0104 chemical sciences Catalysis Solvent alpha-tocopherol Scientific method Yield (chemistry) d l-alpha-tocopherol Organic chemistry Physics::Chemical Physics Selectivity organic-chemistry Microwave |
| Zdroj: | RSC Advances. 6:63515-63518 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c6ra13138g |
| Popis: | A novel protocol for the microwave-assisted synthesis of (all-rac)-α-tocopherol, including its C10- and C15-analogues, is reported. A rotating microwave reactor working under vacuum favoured the rapid evaporation of condensation water and solvent at the end of the process. The main advantages of this fast procedure are its good yield, selectivity, versatility, lower solvents and energy consumption, easier workup and-scalability. |
| Databáze: | OpenAIRE |
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