Roles of pleiotrophin in tumor growth and angiogenesis
| Autor: | Marina Koutsioumpa, Constantinos M. Mikelis, Katerina Theochari, Dionyssios Vourtsis, Margarita Lamprou, Panagiotis Boudouris, Evangelia Papadimitriou, Evanthia Sfaelou, Christina Theodoropoulou, Sotiria Tsirmoula, Evgenia Lampropoulou |
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| Rok vydání: | 2010 |
| Předmět: |
Nervous system
Neovascularization Pathologic Angiogenesis Growth factor medicine.medical_treatment Clinical Biochemistry Immunology Biology Pleiotrophin medicine.anatomical_structure Gene Expression Regulation Neoplasms Cancer research medicine Immunology and Allergy Animals Cytokines Humans Tumor growth Signal transduction Receptor Carrier Proteins Promoter Regions Genetic Cell Proliferation |
| Zdroj: | European cytokine network. 20(4) |
| ISSN: | 1952-4005 |
| Popis: | Pleiotrophin (PTN) is a heparin-binding growth factor with diverse biological activities, the most studied of these being those related to the nervous system, tumor growth and angiogenesis. Although interest in the involvement of PTN in tumor growth is increasing, many questions remain unanswered, particularly concerning the receptors and the signaling pathways involved. In this review, we briefly introduce PTN, and summarize data on its involvement in tumor growth and angiogenesis, and on what is known to date concerning the receptors and pathways involved. |
| Databáze: | OpenAIRE |
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