Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases

Autor:	Pietro Mancosu, Fiorenza De Rose, Ciro Franzese, Davide Franceschini, Antonella Fogliata, Giuseppe D'Agostino, Stefano Tomatis, Marta Scorsetti, Luca Cozzi, Tiziana Comito, Pierina Navarria
Rok vydání:	2016
Předmět:	Adult Male Cancer Research Stereotactic body radiation therapy Radiosurgery 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Overall survival Humans Radiometry Lymph node Aged Pelvic Neoplasms Actuarial Analysis Aged 80 and over Photons Solitary metastasis business.industry Radiotherapy Planning Computer-Assisted High intensity Radiotherapy Dosage General Medicine Middle Aged Dose prescription Treatment Outcome medicine.anatomical_structure Oncology Abdominal Neoplasms Lymphatic Metastasis Positron-Emission Tomography 030220 oncology & carcinogenesis Photon beams Female Lymph Nodes Radiotherapy Intensity-Modulated Tomography X-Ray Computed business Nuclear medicine
Zdroj:	Cancer Investigation. 34:348-354
ISSN:	1532-4192 0735-7907
Popis:	Aim: To study clinical outcome for oligometastatic patients (abdominal lymph-node metastases) treated with stereotactic body radiation therapy. Materials and methods: Seventy-one patients were studied retrospectively. Dose prescription was 45 Gy in six fractions. Clinical outcome was assessed with actuarial analysis. Results: The median follow-up was 1.5 years; 45 patients (63.3%) had solitary metastasis, and 26 (36.6%) had multiple lesions. Local control was achieved in 97.5% with a 1-year actuarial rate of 83%. Two-year progression-free survival was 63.1%, and the overall survival was 76.9%. Two patients (3%) developed grade 2 gastro-enteric toxicity. Conclusions: The treatment provided adequate clinical response in the management of oligometastatic cases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997222f6c1b8f1400ea198842d9b92cb https://doi.org/10.1080/07357907.2016.1197235 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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