Choriocapillaris Assessment In Patients Under Mek-Inhibitor Therapy For Cutaneous Melanoma: An Optical Coherence Tomography Angiography Study
| Autor: | Jorgos Koulalis, Robert W Kuijpers, Marcel P. M. ten Tusscher, Pieter Nelis, Giuseppe Fasolino, Bart Neyns, Gil Awada, Peter Van Elderen |
|---|---|
| Přispěvatelé: | Faculty of Medicine and Pharmacy, Ophtalmology - Eye surgery, Laboratory of Molecular and Medical Oncology, Clinical sciences, Internal Medicine, Emergency Medicine, Medical Oncology, Laboratory of Molecullar and Cellular Therapy, Surgical clinical sciences, Neuroprotection & Neuromodulation |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Skin Neoplasms Fundus Oculi octa Ophthalmology Retinal capillary MEK-inhibitor Humans Medicine In patient Fluorescein Angiography Melanoma Mitogen-Activated Protein Kinase Kinases Plexus Choroid business.industry MEK inhibitor Retinal Vessels General Medicine Optical coherence tomography angiography medicine.disease OCT choriocapillaris Cutaneous melanoma business Tomography Optical Coherence |
| Zdroj: | Seminars in Ophthalmology. 36:765-771 |
| ISSN: | 1744-5205 0882-0538 |
| DOI: | 10.1080/08820538.2021.1903512 |
| Popis: | PURPOSE: The present study investigates by optical coherence tomography angiography (OCTA) the retinal capillary plexus and choriocapillaris flow voids and their possible correlation with MEKAR. METHODS: 34 eyes of 17 patients (61.5 years [30.4-77.4]) with stage IV cutaneous melanoma were included prospectively. All patients showed disease progression under treatment with Nivolumab/Ipilimumab and were subsequently treated with the MEK-inhibitor Trametinib 2 mg once daily. At the start and every 6 weeks during follow-up of 4 months, patients underwent a complete ophthalmologic exam, OCTA and when needed fluorescein angiography. RESULTS: Statistical analysis was performed on 17 eyes of 9 patients. Eight patients were excluded due to missing OCTA images or due to drop-out because of decease or change of treatment. Comparing vessel area density (P = .625 and 0.681, respectively), vessel skeleton density (P = .996 and 0.766, respectively) of the superficial and deep capillary plexus, flow void number and total flow void area (mm2 and %) (P = .495; 0.197 and 0.298, respectively) of choriocapillaris slab, before and after treatment, revealed no significant difference. The evolution of choriocapillaris flow void parameter did not significantly differ in patients, who developed MEKAR compared to patients who did not. CONCLUSION: In patients receiving MEK-inhibitor with and without MEKAR, no significant different characteristics of the retinal capillary plexus and choriocapillaris were found. These data suggest that the development of MEKAR, has no correlation with vascular alteration. |
| Databáze: | OpenAIRE |
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