Influence of chicken and human lipoproteins on steroidogenesis in granulosa cells of the domestic fowl (Gallus domesticus)
| Autor: | Herbert M. Todd, Frank Hertelendy, Miklós Molnár |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adenosine monophosphate
Very low-density lipoprotein medicine.medical_specialty Lipoproteins Fowl 8-Bromo Cyclic Adenosine Monophosphate Stimulation In Vitro Techniques Lipoproteins VLDL Biology chemistry.chemical_compound Follicle Endocrinology Internal medicine medicine Animals Progesterone Granulosa Cells Forskolin Dose-Response Relationship Drug Cholesterol Colforsin Luteinizing Hormone biology.organism_classification Lipoproteins LDL chemistry Female lipids (amino acids peptides and proteins) Animal Science and Zoology Lipoproteins HDL Chickens Lipoprotein |
| Zdroj: | General and Comparative Endocrinology. 85:335-340 |
| ISSN: | 0016-6480 |
| DOI: | 10.1016/0016-6480(92)90077-w |
| Popis: | When freshly dispersed granulosa cells from the largest preovulatory follicle were incubated in the presence of very low density (VLDL), low density (LDL), or high density (HDL) lipoproteins isolated from sera of laying hens, production of both basal and LH-stimulated progresterone was significantly increased in a dose-related manner. VLDL, the principal transporter of cholesterol to the ovum, appeared to be the most efficacious. A highly significant potentiation of the steroidogenic action of 8-bromo-cyclic adenosine monophosphate and forskolin was also observed. Human LDL, and especially HDL, caused significant stimulation of progesterone production by these cells. It is suggested that the release of cholesterol from lipoproteins taken up by granulosa cells raises the precursor pool for steroidogenesis. This mechanism is further enhanced by a cyclic AMP-mediated mechanism. |
| Databáze: | OpenAIRE |
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