Subchronic toxicity evaluation of ethanol extract of Cassia tora L. seeds in rats
| Autor: | Ho-Kyung Jung, Mu-Jin Lee, Je-Oh Lim, Kiho Lee, Ji-Hun Jang, Hyun Joo Lee, Jong-Choon Kim, Beo-Deul Yang, Hyun-Woo Cho, Sun-Ra Kim, Ho Park, Jong-Hyun Nho, Hae-Sung Park |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Cassia tora No-observed-adverse-effect level Urinalysis Cassia Administration Oral 010501 environmental sciences Toxicology 030226 pharmacology & pharmacy 01 natural sciences Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Oral administration medicine Animals Adverse effect 0105 earth and related environmental sciences Estrous cycle No-Observed-Adverse-Effect Level Traditional medicine medicine.diagnostic_test Ethanol business.industry Plant Extracts Toxicity Tests Subchronic General Medicine Sperm Rats Seeds Histopathology Female Medicine Traditional business |
| Zdroj: | Regulatory toxicology and pharmacology : RTP. 109 |
| ISSN: | 1096-0295 |
| Popis: | Cassia tora Linn. is an annual or perennial plant of the Fabaceae/Leguminosae family. It is used in traditional medicine for various biological activities including anti-constipation, anti-inflammatory, visual acuity, and hepato-protective activities. The present study was carried out to investigate the potential toxicity of C. tora L. seed ethanol extract (CTSEE) following a 13-week repeated oral administration to Sprague-Dawley rats. CTSEE was administered orally to male and female rats for 13 weeks at 0 (control), 500, 1000, and 2000 mg/kg/day (n = 10, for male and female rats for each dose). Additional recovery groups from the control group and high dose group were observed for a 4-week recovery period. At the end of the treatment and recovery periods, animals were sacrificed, and their organs were weighed and blood samples collected. There were no treatment-related adverse effects in clinical signs, body weight, food consumption, estrous cycle, sperm parameters, urinalysis, hematology, serum biochemistry, necropsy findings, organ weight, and histopathology at any doses tested. Under the present experimental conditions, the no-observed-adverse-effect level of the CTSEE was >2000 mg/kg/day in both genders, and no target organs were identified. |
| Databáze: | OpenAIRE |
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