Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats

Autor: Sotirios K. Karathanasis, Richard G. Peterson, Xiao Lu, Karen M. Zimmerman, Jude E Onyia, Xiaomei Guo, Ghassan S. Kassab
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Blood Glucose
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Vasodilator Agents
Vasodilation
Blood Pressure
Femoral artery
Enos
Vasoconstrictor Agents
Endothelial dysfunction
Adiposity
biology
Pancreatic Elastase
Femoral Artery
medicine.anatomical_structure
Matrix Metalloproteinase 9
medicine.symptom
Rosiglitazone
Cardiology and Cardiovascular Medicine
Blood vessel
medicine.drug
medicine.medical_specialty
Nitric Oxide Synthase Type III
medicine.artery
Internal medicine
medicine
Animals
Hypoglycemic Agents
Triglycerides
Original investigation
Dose-Response Relationship
Drug
business.industry
Body Weight
Myography
nutritional and metabolic diseases
Receptors
Adrenergic
alpha
medicine.disease
biology.organism_classification
Rats
Rats
Zucker
Disease Models
Animal
Endocrinology
Diabetes Mellitus
Type 2
lcsh:RC666-701
Vasoconstriction
Thiazolidinediones
Endothelium
Vascular
business
Diabetic Angiopathies
Myograph
Zdroj: Cardiovascular Diabetology
Cardiovascular Diabetology, Vol 9, Iss 1, p 19 (2010)
ISSN: 1475-2840
Popis: Objectives Endothelial dysfunction precedes atherogenesis and clinical complications in type 2 diabetes. The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect of treatment with rosiglitazone (Rosi) on endothelial function and mechanical remodeling. Methods The Rosi treatment was given to ZDF rats for 3 weeks. The endothelium-dependent vasodilation and α-adrenoceptor-dependent vasoconstriction of femoral arteries were studied using an ex-vivo isovolumic myograph. The biomechanical passive property of the arteries was studied in Ca2+-free condition. The expressions of endothelial nitric oxide synthase (eNOS), α-adrenoceptor, matrix metalloproteinase 9 (MMP9), and elastase were evaluated. Results Endothelium-dependent vasorelaxation of the femoral artery was blunted at low doses in ZDF rats at 11 weeks of age and attenuated at all doses in ZDF rats at 19 weeks of age. The expression of eNOS was consistent with the endothelium-dependent vasorelaxation. The α-adrenoceptor was activated and the mechanical elastic modulus was increased in ZDF rats at 19 weeks of age. The expressions of α-adrenoceptor, MMP9, and elastase were up regulated in ZDF rats at 19 weeks of age. Rosi treatment for 3 weeks restored endothelium-dependent vasorelaxation and the expression of eNOS and the adrenoceptor activation at the doses below 10-6 mole/L in ZDF rats at 19 weeks of age. Rosi treatment for 3 weeks did not, however, improve the mechanical properties of blood vessel, the expressions of α-adrenoceptor, MMP9, and elastase in ZDF rats. Conclusion The endothelial dysfunction and mechanical remodeling are observed as early as 19 weeks of age in ZDF rat. Rosi treatment for 3 weeks improves endothelial function but not mechanical properties.
Databáze: OpenAIRE
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