The evolution of electrocardiographic changes in patients with Duchenne muscular dystrophies
| Autor: | Je Sang Lee, Woo Hyun Yoo, Kwang Hun Kim, Min-Jung Cho, Yong Beom Shin, Peter Chun |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Duchenne muscular dystrophy
medicine.medical_specialty Cardiomyopathy 030204 cardiovascular system & hematology Pediatrics 03 medical and health sciences Electrocardiography 0302 clinical medicine Internal medicine Heart rate medicine Repolarization In patient medicine.diagnostic_test business.industry lcsh:RJ1-570 lcsh:Pediatrics medicine.disease Middle age Heart failure Pediatrics Perinatology and Child Health Cardiology Original Article business Cardiomyopathies 030217 neurology & neurosurgery |
| Zdroj: | Korean Journal of Pediatrics, Vol 60, Iss 6, Pp 196-201 (2017) Korean Journal of Pediatrics |
| ISSN: | 2092-7258 1738-1061 |
| Popis: | Purpose Myocardial dysfunction and dysrhythmias are inevitable consequences of Duchenne muscular dystrophy. We aimed to evaluate specific trends of electrocardiographic changes that reflect the progress of cardiomyopathy in patients with Duchenne muscular dystrophy. Methods Fifty electrocardiograms (ECGs) of 30 patients (ages 1 to 27 years) who had not been prescribed medications for heart failure treatment at the time of examination were retrospectively analyzed and compared with 116 ECGs of age-matched healthy 116 controls. Heart rate, leads with fragmented QRS (fQRS), corrected QT, Tpeak-to-Tend, and Tpeak-to-Tend/QT were analyzed. Results The patients with Duchenne muscular dystrophy failed to show a normal age-related decline in heart rate but showed an increasing trend in the prevalence of fQRS, corrected QT, corrected Tpeak-to-Tend, and Tpeak-to-Tend/QT over time. In the ≤10-year-old patient group, a significant difference was found only in the prevalence of fQRS between the patients and the controls. The prevalence of fQRS, heart rate, Tpeak-to-Tend/QT, and corrected Tpeak-to-Tend demonstrated significant differences between the patients and the controls in the middle age group (11 to 15 years old). All the indexes were statistically significantly different in the ≥16-year-old patient group. Conclusion The prevalence of lead with fQRS representing regional wall motion abnormalities was higher in the young patients than in the young healthy controls, and this might be one of the first signs of myocardial change in the patients. Markers of depolarization and repolarization abnormalities were gradually prominent in the patients aged >10 years. Further studies are needed to confirm these findings. |
| Databáze: | OpenAIRE |
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