The effect of paleolithic diet on glucose metabolism and lipid profile among patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials
| Autor: | Seyedeh Tayebeh Rahideh, Ahmed Abu-Zaid, Sara Abdulrahman Alomar, Mojtaba Lotfi, Mohammad Hassan Sohouli, Saud K AlBatati, Sara A Alkhalifa, Mihnea-Alexandru Găman, Abolfazl Lari, Somaye Fatahi, Abdullah M AlHossan, Maryam Seifishahpar |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty 030309 nutrition & dietetics macromolecular substances Carbohydrate metabolism medicine.disease_cause Industrial and Manufacturing Engineering law.invention 03 medical and health sciences 0404 agricultural biotechnology Randomized controlled trial law health services administration Internal medicine medicine Paleolithic diet Humans Randomized Controlled Trials as Topic 0303 health sciences medicine.diagnostic_test Adult patients business.industry 04 agricultural and veterinary sciences General Medicine Cholesterol LDL 040401 food science Glucose Meta-analysis Diet Paleolithic Insulin Resistance Lipid profile business Food Science |
| Zdroj: | Critical reviews in food science and nutrition. 62(17) |
| ISSN: | 1549-7852 |
| Popis: | Several randomized clinical trials (RCTs) have investigated the effects of the Paleolithic diet (PD) in adult patients suffering from metabolic disorders. However, the results of these RCTs are conflicting. Therefore, we conducted a systematic review and meta-analysis to assess the effects of the PD in patients with metabolic disorders.We searched the PubMed/Medline, Scopus, Cochrane Databases, Google Scholar, Web of Science, and Embase databases up to June, 2020. The data were pooled using a random-effects model. From the eligible publications, 10 articles were selected for inclusion in this systematic review and meta-analysis. The meta-analysis was performed using a random-effects model. The heterogeneity was determined using the IThe pooled results from the random-effects model showed a significant reduction of the homeostatic model assessment of insulin resistance (HOMA-IR) (weighted mean difference, WMD: -0.39, 95% CI: -0.70, -0.08), fasting insulin (WMD: -12.17 μU/mL, 95% CI: -24.26, -0.08), total cholesterol (WMD: -0.32 mmol/l, 95% CI: -0.49, -0.15), triglycerides (WMD: -0.29 mmol/L, 95% CI: -0.42, -0.16), low-density lipoprotein cholesterol (WMD: -0.35 mmol/L, 95% CI: -0.67, -0.03), blood pressure (BP)(WMD - 5.89 mmHg; 95% CI - 9.973 to - 1.86 for the systolic BP and WMD - 4.01 mmHg; 95% CI - 6.21 to - 1.80 for the diastolic BP values) and C-reactive protein (CRP) levels (WMD: -0.84, mg/L, 95% CI: -1.62, -0.06) in the PD groupOur findings provide better insights into the effect of the PD on the modulation of the glucose and lipid metabolism factors in patients with metabolic disorders, providing comprehensive information for the development of future RCTs with a high quality design. |
| Databáze: | OpenAIRE |
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