Treatment failure of low molecular weight heparin in a patient with an aortic mechanical prosthesis
| Autor: | Giuseppe Dattilo, Salvatore Patanè, Domenico Tulino, Viviana Tulino, Filippo Marte, Annalisa Lamari |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class business.industry medicine.medical_treatment Low molecular weight heparin Heparin Prosthesis Treatment failure Surgery Regimen Aortic prosthesis Internal medicine medicine Oral vitamin Cardiology Prosthetic Valve Thrombosis Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | International Journal of Cardiology. 146:e30-e32 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2008.12.180 |
| Popis: | After mechanical heart valve replacement use of unfractionated heparin is sometimes required because vitamin K antagonists are temporarily contraindicated or to prevent valve-associated thromboembolism until oral vitamin K antagonists take effect. Bridging therapy with a standardized low molecular weight heparin-based regimen has been reported effective and relatively safe in a large cohort of patients with mechanical heart valves. Many cases with mitral mechanical valve prostheses and treatment failure of low molecular weight heparin have also been reported as well as prosthetic valve thrombosis has been reported with adequate anticoagulation. A case has also been reported of well functioning Starr-Edwards aortic prosthesis without anticoagulation. We present a case of cardioembolic stroke in a patient with an aortic mechanical prosthesis in bridging therapy with a standardized low molecular weight heparin-based regimen. This case is illustrative of treatment failure of low molecular weight heparin in a patient with an aortic mechanical prosthesis. |
| Databáze: | OpenAIRE |
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