Slices and Sacs: Limitations on Metabolic and Functional Studies in Kidney Cortex and Intestine

Autor:	E. C. Foulkes
Rok vydání:	1996
Předmět:	Kidney cortex Kidney Cortex Cell Polarity Anatomy In Vitro Techniques Biology General Biochemistry Genetics and Molecular Biology Small intestine Diffusion Intestines medicine.anatomical_structure Intestinal Absorption medicine Animals Humans Special care Functional studies Neuroscience
Zdroj:	Experimental Biology and Medicine. 211:155-162
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-211-43959a
Popis:	While all experimental models, whether based on isolated preparations in vitro or on intact animals, possess characteristic limitations, reliance on simplified systems mandates special care. On the basis of both older and new evidence, the present review emphasizes problems associated especially with the use of renal cortical slices and everted sacs of the small intestine. Although these preparations have found renewed acceptance, the significance of results obtained is still at times interpreted without due regard for physiological reality. Sacs and slices will undoubtedly continue to prove useful in the study of biological processes, but their application must be predicated upon recognition of what information they can or cannot yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99697023aa6a6abbd3e354bcb5c1cdac https://doi.org/10.3181/00379727-211-43959a Zobrazit plný text záznamu